Every year, more than 700,000 patients in the United States undergo joint replacement surgery. The procedure—in which a knee or a hip is replaced with an artificial implant—is highly invasive, and many patients delay the surgery for as long as they can.



Jennifer Elisseeff, a biomedical engineer at Johns Hopkins University, hopes to change that with a treatment that does away with surgery entirely: injectable tissue engineering. She and her colleagues have developed a way to inject joints with specially designed mixtures of polymers, cells, and growth stimulators that solidify and form healthy tissue. “We’re not just trying to improve the current therapy,” says Elisseeff. “We’re really trying to change it completely.”

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