Cows have been engineered to produce antitumor compounds in their blood, suggesting a new way of manufacturing complex therapeutic proteins.

Gottfried Brem of the University of Veterinary Medicine in Vienna and colleagues have shown that cloned, transgenic animals can be used to produce a special type of antitumor antibody.

“Such antibodies are often difficult and sometimes even impossible to produce in sufficient yield and quality using conventional expression systems, that is, cultured bacteria, insect cells, yeast, or mammalian cells carrying the gene of interest,” say the researchers.

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