Two new gene tweaks have been discovered that make mice resistant to obesity, findings that could be used to develop fat-fighting drugs.

By altering the expression of a single, but different, gene, two independent research groups have created strains of transgenic mice that don’t gain weight, even when fed fatty, calorie-rich diets.

While observing existing transgenic mice that contain the alpha-to-beta gene substitution, they found that the mice live up to five months longer than their wild counterparts. Also, they were leaner, despite eating more than the wild mice.

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