For those itching to blow past Dvorak and just have at it with their keyboard layout, the Ergodex DX-1 Input System is perfect. It includes 25 keys which you can position on an included tray any which way, binding them as you see fit.

Yes, I realize this isn’t intended to replace your standard keyboard, lacking enough keys for even the alphabet.) The keys communicate wirelessly with the base pad, giving you plenty of freedom for your layout. The input system costs $150 and includes the keys and base pad, along with the binding software which allows you to generate complex macros for any key on the pad. The complete system has a lead time of 2-4 weeks right now, so you may want to place your order now.

More here.