As the holidays quickly approach, many weight-loss resolutions are made in order to start the new year fresh. However, new discoveries may help with the battle of the bulge.
Researchers at Yale University have discovered a new molecule that could suppress hunger after eating a fatty meal.
This research suggests that the molecule may help control how much people and animals eat. A family of lipids called N-acylphosphatidylethanolamines (NAPEs) were studied. These lipids are synthesized and secreted into the blood by the small intestine after eating fatty foods.
Conducting their study on mice and rats, the researchers found that those injected regularly with NAPEs ate less food and lost weight. Being treated with NAPEs seemed to reduce the activity of the neurons in the brain controlling hunger.
Researchers are now planning on carrying out their research on humans but will first study non-human primates. “If chronic NAPE treatment is well tolerated and can cause weight loss by a reduction of food intake, we would have strong impetus to move forward with human NAPE trials,” stated Gerald I. Shulman, Yale professor of medicine and cellular & molecular physiology and a Howard Hughes Medical Institute investigator.
This research is published in the November 26 issue of the journal Cell.