‘Missing Link’ In Immune Response To Disease: Sheer Mechanical Force

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A highly focused laser beam (at right) is used to apply mechanical force (shown as a double headed arrow) to a microsphere (white) coated with histocompatibility protein.

The immune system’s T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.

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