Mechanism Behind Organ Transplant Rejection Identified

Heart-transplant blood vessel in chronic rejection

UCLA researchers have pinpointed the culprit behind chronic rejection of heart, lung and kidney transplants. Published in the Nov. 23 edition of Science Signaling, their findings suggest new therapeutic approaches for preventing transplant rejection and sabotaging cancer growth.

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Gene Therapy for Metastatic Melanoma?

DO NOT DRINK… Trust me, i know what its made of!

A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation.

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Bioengineers and the latest Adult Stem Cells Breakthrough!

Finally, the perfect environment provided for stem cell research!

Bioengineers from the University of California, San Diego have achieved the “Triple Crown” of stem cell culture — they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation.

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Embryonic Stem Cell Culturing Grows from Art to Science

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Embryonic stem cells under microscope

Growing human embryonic stem cells in the lab is no small feat. Culturing the finicky, shape-shifting cells is labor intensive and, in some ways, more art than exact science. Continue reading… “Embryonic Stem Cell Culturing Grows from Art to Science”

Acne Drug Prevents HIV Breakout

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Janice E. Clements, Ph.D.

Johns Hopkins scientists have found that a safe and inexpensive antibiotic in use since the 1970s for treating acne effectively targets infected immune cells in which HIV, the virus that causes AIDS, lies dormant and prevents them from reactivating and replicating.

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‘Good’ Bacteria Keep Immune System Primed to Fight Future Infections

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Bacteria (Streptococcus pneumoniae, red) under attack by a neutrophil (blue).

Scientists have long pondered the seeming contradiction that taking broad-spectrum antibiotics over a long period of time can lead to severe secondary bacterial infections. Now researchers from the University of Pennsylvania School of Medicine may have figured out why.

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Llama Proteins Could Play a Vital Role in the War on Terror

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Two llama ignoring the view of Machu Picchu.

Scientists at the Southwest Foundation for Biomedical Research (SFBR) have for the first time developed a highly sensitive means of detecting the seven types of botulinum neurotoxins (BoNTs) simultaneously.

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‘Missing Link’ In Immune Response To Disease: Sheer Mechanical Force

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A highly focused laser beam (at right) is used to apply mechanical force (shown as a double headed arrow) to a microsphere (white) coated with histocompatibility protein.

The immune system’s T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.

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New Synthetic Molecules Trigger Immune Response To HIV And Prostate Cancer

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Artist’s rendering of viruses. Scientists have developed synthetic molecules capable of enhancing the body’s immune response to HIV and HIV-infected cells, as well as to prostate cancer cells.

Researchers at Yale University have developed synthetic molecules capable of enhancing the body’s immune response to HIV and HIV-infected cells, as well as to prostate cancer cells. Their findings, published online in the Journal of the American Chemical Society, could lead to novel therapeutic approaches for these diseases.

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Major Step In Making Better Stem Cells From Adult Tissue

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Scientists have developed new technique that is 200 times more efficient and twice as fast as conventional methods for transforming adult human cells into induced pluripotent stem cells.

A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine.

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New Strategy For Mending Broken Hearts?

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This immunofluorescence staining image shows the cardiomyocytes in green and the fibroblasts interspersed around them in red. The cells are aligned around the central pore.

By mimicking the way embryonic stem cells develop into heart muscle in a lab, Duke University bioengineers believe they have taken an important first step toward growing a living “heart patch” to repair heart tissue damaged by disease.

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‘Liposuction Leftovers’ Easily Converted To Induced Pluripotent Stem Cells

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Rendering of human fat cells.

Globs of human fat removed during liposuction conceal versatile cells that are more quickly and easily coaxed to become induced pluripotent stem cells, or iPS cells, than are the skin cells most often used by researchers, according to a new study from Stanford’s School of Medicine Continue reading… “‘Liposuction Leftovers’ Easily Converted To Induced Pluripotent Stem Cells”