The summit of human endurance may also hold clues to preserving the brain. Scientists at the Broad Institute and Mass General Brigham have discovered that exposing Parkinson’s disease models to low-oxygen environments—the kind found at Mount Everest base camp—can both protect and restore brain function. The finding challenges one of neuroscience’s long-held assumptions: that oxygen is always good for the brain.
Parkinson’s disease affects more than 10 million people worldwide, eroding motor control as neurons die and toxic protein clumps called Lewy bodies accumulate. Traditional therapies try to address symptoms, but they do little to preserve the neurons themselves. What the Broad-MGH team found is that too much oxygen may be part of the problem. Damaged mitochondria, the energy factories of brain cells, stop using oxygen efficiently, leading to dangerous buildup. This excess oxygen appears to act more like a toxin than a nutrient, fueling the neurodegeneration that underpins Parkinson’s.
Continue reading… “Breathing Like Everest: Low Oxygen as a Potential Parkinson’s Therapy”