CRISPR has been hailed as the most revolutionary tool in modern medicine—a molecular scalpel capable of rewriting the code of life itself. But despite its breathtaking promise, the technology has been hobbled by one stubborn obstacle: delivery. Getting CRISPR machinery into the right cells, in the right tissues, at the right time has often been more of an art than a science, with inefficiencies and risks that have slowed its path from the lab to the clinic.
Now researchers at Northwestern University have unveiled a breakthrough that could tip the balance. By wrapping CRISPR inside spherical nucleic acids (SNAs) built from strands of DNA, the team has created a delivery vehicle that triples efficiency, dramatically reduces toxicity, and expands the range of cells that can be edited. These tiny, DNA-coated nanoparticles—known as LNP-SNAs—are rewriting the rules of genetic medicine.
Continue reading… “DNA-Wrapped Nanoparticles Triple CRISPR’s Power—and Open the Door to a New Era of Genetic Medicine”