Advance in CAR T-cell therapy eliminates severe side effects

9462BBC5-4F9E-44BE-8060-D2F28918C5AAScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAID

An advance in the breakthrough cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings, a new USC study shows.

“This is a major improvement,” said Si-Yi Chen of the USC Norris Comprehensive Cancer Center, professor in the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC, and senior author of the study appearing online April 22 in Nature Medicine. “We’ve made a new CAR molecule that’s just as efficient at killing cancer cells, but it works more slowly and with less toxicity.”

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New gene therapy wipes out leukemia in three patients

gene therapy

The new gene therapy to treat leukemia uses the patients’ own blood cells to hunt down and wipe out their cancer.

The first clear success with gene therapy to treat leukemia, turning the patients’ own blood cells into assasins that hunt down and wipe out their cancer has been reported by scientists at the University of Pennsylvania.

 

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