Category: Cancer

By Wale Azeez  

Researchers at the Massachusetts Institute of Technology (MIT) have created a nanoparticle diagnostic tool that can detect cancer cells in urine.

The tool, invisible to the naked eye at less than 100 nanometres wide, could also be modified to work as an imaging agent to highlight a confirmed cancerous tumour’s location from a scan.

According to the researchers, the nanoparticle tool, once approved for human use, could be incorporated into routine medical urine tests to screen for traces of cancer cells.

If cancer is found, the patient could be given the nanoparticle to ingest before undergoing a Positron Emission Tomography (PET) imaging scan to find the source of the disease.

Continue reading… “This nanoscopic tool could help doctors detect cancer in a routine urine test”

Newswise — Researchers at Wake Forest School of Medicine have shown that a targeted therapy using non-thermal radio waves is safe to use in the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer. The therapy also showed a benefit in overall survival.

The study findings appear online in 4Open, a journal published by EDP Sciences.

“HCC accounts for nearly 90% of all liver cancers, and current survival rates are between six and 20 months,” said Boris Pasche, M.D., Ph.D., chair of cancer biology and director of Wake Forest Baptist’s Comprehensive Cancer Center. “Currently, there are limited treatment options for patients with this advanced liver cancer.”

For the study researchers used a device called TheraBionic P1, invented by Pasche and Alexandre Barbault of TheraBionic GmbH in Ettlingen, Germany, that works by delivering cancer-specific, amplitude-modulated radiofrequency electromagnetic fields (AM RF EMF) programmed specifically for HCC. 

Continue reading… “Radio-wave Therapy Is Safe for Liver Cancer Patients and Shows Improvement in Overall Survival”

The pipes imprinted on microfluidic chips are about the size of a human hair, and in many ways are like miniaturizing a chemical manufacturing plant. (Katherine Elvira), Author provided

Continue reading… “New cancer treatments can be tested in artificial cells on tiny chips the size of a postage stamp”

Hisataka Kobayashi (right), senior investigator at the U.S. National Institutes of Health, shakes hands with Rakuten Group Inc. Chairman and Chief Executive Officer Hiroshi Mikitani

A new cancer treatment that uses light to target and kill only cancer cells, and is believed to have few side effects, has entered into use in Japan, in a world first.

In the treatment, called photoimmunotherapy, antibodies that bind only to cancer cells are administered to patients.

Harmless by themselves, the antibodies, when illuminated for several minutes with near-infrared lasers, trigger a chemical reaction that “destroy only cancer cells with pinpoint accuracy,” according to Hisataka Kobayashi, senior investigator at the U.S. National Institutes of Health, who developed the method.

Continue reading… “Japan launches new cancer treatment using special antibodies and beams of light”

Following its success against COVID-19, BioNTech is now focused on its cancer vaccines.

By  Ameya Paleja

Buoyed by the success of its mRNA technology against COVID-19, BioNTech is now focused on its cancer vaccines. The company recently began dosing patients for its Phase II trial for an advanced melanoma vaccine in the European Union.

BioNTech calls itself a “next-generation immunotherapy company pioneering in therapies for cancer and other serious diseases.” The COVID-19 vaccine was a minor detour for the company. The company’s product pipeline is filled with mRNA vaccines targeting different types of cancers, most of which are in preclinical stages. BioNTech recently began the Phase II trial of BNT111, which will test its mRNA vaccine in combination with an antibody-drug, Libtayo, in patients with anti-PD1-relapsed Stage III/ IV melanoma. Libtayo is the commercial name for cemiplimab, co-developed by Regeneron and Sanofi, and is an anti-PD-1 monoclonal antibody.

Continue reading… “BioNTech Now Aims Its mRNA Technology at Cancer”

BY JIM GOODWIN-WUSTL

“We think this is the first report of the use of a neoantigen DNA vaccine in a human, and our monitoring confirms the vaccine was successful in prompting an immune response that targeted specific neoantigens in the patient’s tumor,” William Gillanders says.

Researchers have shown that personalized cancer vaccines made using DNA can program the immune system to attack malignant tumors, including breast and pancreatic cancers.

The researchers conducted the study in mice with breast cancer and one patient with late-stage pancreatic cancer.

The COVID-19 vaccines—designed using bits of genetic information that prime our immune systems to recognize and fight off viral infections—have become lifesavers in the global fight to end the pandemic.

Now, the new research has shown that a similar vaccine approach can be used to create personalized vaccines that program the immune system to attack malignant tumors, including breast and pancreatic cancers.

The tailor-made vaccines are designed to target mutated proteins called neoantigens that are unique to a patient’s tumors. Unlike the COVID-19 vaccines made by Moderna and Pfizer/BioNTech that rely on genetic material called mRNA, the personalized cancer vaccines are made using DNA.

Continue reading… “DNA-BASED CANCER VACCINE TRIGGERS IMMUNE ATTACK ON TUMORS”

Figure 1 Cathepsin S (CS) protein expression levels are induced through the -1048 promoter fragment from the CTTS gene upon Paclitaxel or hydrogen peroxide stimulation. HEK293 and 769P cells were stimulated with increasing doses of Paclitaxel (Pac) and hydrogen peroxide (HP) and soluble lysates prepared after 24 h and equal volumes analyzed by Western blotting for cathepsin S (CS), BAX and actin expression (Panel A). Similarly, total RNA was isolated from cells stimulated for 24 h with increasing doses of Pac or HP and equal quantities of template cDNA analyzed for transcriptional expression of CS, BAX and Glyceraldehyde-3-phosphate dehydrogenase (GAP-DH, Panel B). Promoter fragments, derived from the transcriptional start site of the CTTS gene to -1048 and -564, were PCR cloned and fused to a promoter-less GFP encoding plasmid (Panel C) and evaluated for GFP expression in equal volumes of HEK293 and 769P cleared whole cell lysates (WCLs) under Pac (10 μg/mL and 5 μg/mL, respectively) or HP (5 μM) stimulatory conditions. GFP expression was also quantified, standardized and corrected against GFP expression from cells stimulated with carrier alone and is shown as a fold change over basal GFP expression (Panel D). HEK293 cells transfected with pCS-1048 or pCS-564 and stimulated with Pac (5 μg/mL) for 24 h were also fixed and visualized for GFP expression using laser scanning confocal microscopy (Panel E). The red bar indicates 1 micron. Quantified data are presented as the mean ± SEM and its significance (where p < 0.05) determined, using a two-way Student’s t-test (* p < 0.05, ** p < 0.01 and *** p < 0.001).

An innovative new technique that encourages cancer cells in the kidneys to self-destruct could revolutionize the treatment of the disease, a new study in the journal Pharmaceutics reports.

During this unique study, researchers from the University of Surrey and Sechenov First Moscow State Medical Universityin Russia investigatedwhethercertain naturally occurring proteins within the body can be used treat cancer.

Continue reading… “Innovative technique developed to destroy cancerous kidney cells”