The new temperature method is based on a “poly(organophosphazene)-based temperature-sensitive hydrogel.”

A team of scientists has developed a new biocompatible bio-ink that can be used to 3D print artificial organs, such as livers and pancreases, that can be transplanted into humans. The researchers, led by Dr. Ali Khademhosseini, a professor of bioengineering at the University of California, Los Angeles, created the new ink by combining alginate, gelatin, and a glycoprotein called recombinant human collagen.

According to Khademhosseini, the new bio-ink has several advantages over previous formulations. “The new ink is biocompatible and can support cell growth and differentiation, which is essential for creating functioning tissues,” he explained. “Additionally, it has the necessary mechanical properties to be 3D printed into complex structures.”

To test the new bio-ink, the team 3D printed a liver-like structure and then seeded it with liver cells. After a week, the cells had grown and formed a functioning tissue that could perform some of the functions of a real liver.

“This breakthrough has the potential to revolutionize the field of organ transplantation,” said Dr. Khademhosseini. “It could provide a more reliable and efficient way to create artificial organs for patients in need of transplants.”

However, there is still much work to be done before this technology can be used in clinical settings. “We need to conduct further research and testing to optimize the ink’s properties and ensure its safety and effectiveness,” Khademhosseini added.

Despite these challenges, the development of this new bio-ink is a significant step forward in the field of 3D printing of artificial organs. “Our ultimate goal is to create functional organs that can be transplanted into patients,” Khademhosseini said. “While we still have a long way to go, this new bio-ink brings us one step closer to achieving that goal.”

By The Impactlab