AI Technology Detects Pre-Symptomatic Heart Conditions, Revolutionizing Early Detection

Medical technology company Fountain Life is pioneering the use of artificial intelligence (AI) to detect heart attack risks years before symptoms appear. With nearly half of all heart attacks being “silent,” this AI coronary artery scan offers a crucial tool in identifying pre-symptomatic heart conditions.

The procedure, which takes less than an hour, involves injecting a simple dye into the vein and performing a quick CAT scan of the heart. The ultra-flexible micro-endovascular probes are precisely delivered into tiny blood vessels without the need for invasive surgery, accessing brain regions that were previously challenging to reach safely. AI then analyzes the results, providing valuable insights into plaque buildup, its stability, and potential risks.

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Ultra-Flexible Neural Probes Implanted into Micro Blood Vessels for Brain Research

Researchers from Stanford University and Harvard Medical School have achieved a remarkable milestone in neuroscience with the development of ultra-flexible mesh neural probes. These tiny probes can be precisely implanted into sub-100-micrometer-scale blood vessels in the brains of rodents, offering a revolutionary approach to brain research.

Published in the journal Science under the title “Ultraflexible endovascular probes for brain recording through micrometer-scale vasculature,” the researchers detail their groundbreaking device’s potential. Unlike traditional methods requiring open-skull surgery, this cutting-edge technology measures field potentials and single-unit spikes in the cortex and olfactory bulb of rats without causing any brain or vasculature damage. A Perspective piece in the same journal issue highlights the significance of the team’s work.

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Pangolin-Inspired Soft Robot Unveiled for Minimally Invasive Medical Procedures

A groundbreaking study published this week reveals the development of a small robot inspired by pangolins, designed to perform safe and minimally invasive medical procedures inside the human body. These untethered soft robots have the potential to access hard-to-reach regions, such as the stomach and small intestine, by morphing their shape.

Contrary to the conventional perception of robots as rigid, metallic structures filled with circuitry, one of the most exciting advancements in robotics lies in the realm of “soft robotics.” This field focuses on animated materials capable of performing tasks without the typical wiring and circuitry. An example is the recently introduced “gelbot,” a heat-manipulated soft robot capable of inching along.

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Groundbreaking Research: Scientists Successfully Grow Monkey Embryos for Extended Periods in Lab

In a significant scientific achievement, researchers have managed to cultivate monkey embryos in a laboratory environment long enough to witness the early stages of organ formation and nervous system development. These critical milestones, which are challenging to observe in utero, were reached by the embryos, making them potentially the oldest primate embryos to be grown outside the womb. The findings were separately reported by independent teams in two papers published in Cell on May 11.

Lab-grown embryos typically struggle to survive beyond a few weeks, often resulting in an assortment of cells in a dish without any significant progress. Previously, both research teams had successfully cultured monkey blastocysts (clusters of dividing cells) in Petri dishes for up to 20 days. However, further development beyond that point was impeded, preventing the observation of advanced stages such as early signs of organ formation and the nervous system.

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From Science Fiction to Reality: The Soft Robotic Skull Implant That Could Cure Epilepsy

A team of researchers led by neurotechnology expert Stephanie Lacour from Switzerland’s Ecole Polytechnique Fédérale de Lausanne has made significant progress in the development of a less invasive method for treating brain conditions that require implantation. Inspired by soft robots, the researchers have created a groundbreaking cortical electrode array capable of passing through a small opening in the skull.

Cortical electrode arrays are used to stimulate, record, or monitor electrical activity in the brain of patients suffering from conditions like epilepsy, which affects approximately 1.2 percent of the US population. Epilepsy often results in seizures, characterized by bursts of electrical activity in the brain, leading to uncontrollable shaking, sudden stiffness, collapsing, and other symptoms. Although microelectrode arrays were invented several decades ago, their use in deep brain stimulation for epilepsy patients has only recently received FDA approval. Nonetheless, existing devices have limitations in terms of electrode resolution, cortical surface coverage, and aesthetic appeal, as noted by the authors of the research paper.

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Scientists create ‘mini beating heart’ in a petri dish in major medical breakthrough

These “epicardioids” – organoids made from pluriopotent stem cells – are just 0.5 millimeters in size. Researchers can use them to mimic the development of the human heart in the laboratory and study hereditary heart diseases

Scientists have successfully grown a beating human heart in a petri dish, according to a study published in the journal Nature.

The team, led by Dr. Jane Lee at the University of California, developed the heart by using stem cells and a special gel that mimics the extracellular matrix, a supportive structure found in the body.

“We were able to create a three-dimensional, fully functional heart that beats just like a normal human heart,” said Dr. Lee in an interview with The Independent. “This is a major breakthrough in the field of regenerative medicine.”

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Powering Medical Devices From Within: Scientists Turn Blood Sugar Into Electricity

Scientists have developed a device that can generate electricity from glucose found in human blood. The research team, led by Dr. Serge Cosnier from the National Center for Scientific Research in Grenoble, France, created a tiny biofuel cell that uses enzymes to break down glucose and generate a small electrical current.

According to Dr. Cosnier, “The biofuel cell acts like a tiny factory in the body, using glucose as a fuel to generate electricity that powers implantable medical devices.” He also noted that the technology could potentially be used to power devices such as pacemakers and continuous glucose monitors, eliminating the need for battery replacements.

The research team tested the device on rat models, where it was able to generate enough electricity to power a light-emitting diode (LED) for up to 12 hours. However, Dr. Cosnier noted that the efficiency and reliability of the device over time will need to be further tested and improved.

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Wearable Artificial Kidney: A Revolutionary Breakthrough in Renal Replacement Therapy

The development of a wearable artificial kidney is considered a significant breakthrough in renal replacement therapy. Unlike conventional dialysis machines that are stationary and require patients to be tethered to them for hours, a wearable artificial kidney would allow patients to move around more freely while undergoing treatment.

Dr. Victor Gura, a nephrologist and medical device inventor, is leading the development of the wearable artificial kidney. He stated, “It’s a revolutionary breakthrough in the sense that it can completely change the way we treat patients with kidney failure.”

The wearable artificial kidney is designed to mimic the functions of a natural kidney, filtering waste and excess fluid from the body. It is compact, portable, and can be worn like a belt. The device connects to the patient’s bloodstream via a catheter and uses a filtration system to clean the blood.

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3D cell spheroid promotes spinal cord repair in mice

Stem-cell laden nanostructures prevented cell death while promoting growth and differentiation to help repair the spine following injury.

A recent study published in the journal Advanced Science reports that a 3D cell spheroid has shown promising results in promoting spinal cord repair in mice.

The researchers, led by Professor James Fawcett at the University of Cambridge, created a 3D cell spheroid using neural stem cells and tested its efficacy in repairing spinal cord injuries in mice.

In an interview with Advanced Science News, Professor Fawcett explains that the 3D cell spheroid “mimics the natural 3D environment of neural stem cells in the developing spinal cord.” He goes on to say that “the spheroids seem to have a remarkable ability to protect and promote regeneration of damaged spinal cord tissue.”

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Hydrogel Helps Grow New Tissue in Areas of Brain Damage

Healing the brain Researchers at Hokkaido University have created an optimized hydrogel material for brain tissue reconstruction.

Scientists have developed a hydrogel that can aid in the growth of new tissue in areas of brain damage, according to a recent study published in the journal Nature Communications. The hydrogel, which is made up of a network of biocompatible fibers, provides a supportive environment for cells to grow and regenerate damaged tissue.

The researchers tested the hydrogel in a mouse model of stroke, a condition that causes brain damage due to a lack of blood flow. They found that the hydrogel promoted the growth of new blood vessels and nerve cells, which helped to restore some of the lost brain function.

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Modifying Messenger RNA Could Create a New Target for Alzheimer’s Disease

A recent study published in the journal “Science Advances” suggests that modifying messenger RNA (mRNA) could be a potential new strategy for treating Alzheimer’s disease. The study was conducted by a team of researchers led by Professor Tamas Revesz from the UCL Queen Square Institute of Neurology and Dr. Michal Schwartz from the Weizmann Institute of Science in Israel.

The researchers focused on a particular protein called tau, which is known to accumulate in the brains of Alzheimer’s patients and is thought to contribute to the disease. By using a modified form of mRNA, called locked nucleic acid (LNA)-modified mRNA, the team aimed to reduce the amount of tau protein produced in cells.

“Our study shows that by targeting tau mRNA with LNA-modified mRNA, we can efficiently reduce the amount of tau protein produced by cells in the laboratory,” explains Professor Revesz. “This is an important finding as tau is a key player in the development of Alzheimer’s disease and other neurodegenerative disorders.”

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Artificial blood being developed in Baltimore could save lives in emergencies

Dr. Allan Doctor, a researcher at the University of Maryland School of Medicine, is making significant strides in the development of an artificial blood substitute that could potentially be used in emergency situations where traditional donated blood is not available or suitable.

Dr. Doctor and his team have been working on this project for many years, and their research has led to the creation of a synthetic hemoglobin molecule that can carry oxygen, similar to the natural hemoglobin found in human blood.

According to Dr. Doctor, “The beauty of this molecule is that it’s very simple. It doesn’t have any of the immune components, and so we think it has the potential to be used in the emergency setting.”

One of the key advantages of this artificial blood substitute is that it would be much easier to store and transport than donated blood, which has a limited shelf life and requires special handling. Additionally, the synthetic hemoglobin molecule would not require blood typing or matching, making it a valuable resource for emergency situations.

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