New Wearable Sensor Detects Even More Compounds in Human Sweat

If you have ever had your blood drawn, whether to check your cholesterol, kidney function, hormone levels, blood sugar, or as part of a general checkup, you might have wondered why there is not an easier, less painful way.

Now there might be. A team of researchers from Caltech’s Cherng Department of Medical Engineering has unveiled a new wearable sensor that can detect in human sweat even minute levels of many common nutrients and biological compounds that can serve as indicators of human health.

The sensor technology was developed in the lab of Wei Gao, assistant professor of medical engineering, Heritage Medical Research Institute investigator, and Ronald and JoAnne Willens Scholar. For years, Gao’s research has focused on wearable sensors with medical applications, and this latest work represents the most precise and sensitive iteration yet.

“We’ve done wearable sweat sensors before,” he says. “There were so many biomarkers we wanted to detect, but in the past we could not. There was no good way.”

Gao says previous versions of his sweat sensors relied on enzymes embedded within them to detect a limited number of relevant compounds. While antibodies could be used in sensors to detect more compounds at low concentrations, that technique had a big weakness: antibodies in the sensor can only be used once, meaning the sensors will wear out.

Continue reading… “New Wearable Sensor Detects Even More Compounds in Human Sweat”
0

Researchers develop ultrasound stickers that can see inside the body

An ultrasound sticker

Researchers have created a stamp-sized ultrasound sticker that can provide images of internal organs continuously for 48 hours.

Currently, ultrasounds require bulky and specialised equipment only available in hospitals and doctors’ offices.

But a new design by Massachusetts Institute of Technology (MIT) engineers might make the technology as wearable and accessible as buying plasters at the pharmacy.

The patch was tested in people doing activities such as jogging and drinking fluids.

Ultrasounds allow doctors to see live images of a patient’s internal organs, and wands and probes are used to direct sound waves into the body.

These waves reflect back out to produce high-resolution images of a patient’s heart, lungs and other deep organs.

MIT graduate student Chonghe Wang said: “Wearable ultrasound imaging tools would have huge potential in the future of clinical diagnosis.

Continue reading… “Researchers develop ultrasound stickers that can see inside the body”
0

Drug that increases human lifespan to 200 years is in the works

Taken in pill form, the drug would eliminate cells in the human body that are responsible for advancing the ageing process – potentially doubling our lifespan. But is this desirable?

By Jessica Byrne

Are you ready to live an additional hundred years?

British computational biologist Dr Andrew Steele has published a new book on the longevity of human life, arguing it is entirely feasible for us to live well beyond a single century with the help of a certain kind of drug.

In the book, he states that research in the field of senolytics – drugs that work to eliminate cells that degrade tissue function – are already showing promising results and could become available on the market within the next decade.

‘I don’t think there is any kind of absolute cap on how long we can live,’ said Dr Steele. ‘I can’t see a physical or biological reason why people couldn’t live to 200 — the challenge is whether we can develop the biomedical science to make it possible.’

Once perfected, the drug would destroy ‘zombie cells’, scientifically known as senescent cells. These cells stop dividing over our lifespan, accumulate inside our bodies, and eventually release compounds that speed up processes of ageing.

In a 2020 trial, mice who were administered the drug showed improved physical function and extended health and lifespan. Given that gene functions in humans and mice are almost identical, many believe we could reap the same benefits.

Continue reading… “Drug that increases human lifespan to 200 years is in the works”
0

Combining AI and Zebrafish to Accelerate Drug Discovery

As part of our SLAS Europe 2022 coverage, we speak to Dr. Javier Terriente, Co-founder and Chief of Drug Development at ZeClinics, about how zebrafish could be the future for discovering new therapeutics.

Please could you introduce yourself and tell us about your role at ZeClinics?

My name is Javier Terriente, and I have a PhD in molecular biology. I spent 15 years in academia, and in 2013 we founded ZeClinics. I am the co-founder of ZeClinics, but I have also been leading the scientific side of the company. I was the scientific director until a couple of years ago, and today I am the chief of drug development.

Essentially, my role now within the company is to lead our internal drug development programs, and I also help with the implementation of new technologies like artificial intelligence and so on. In a way, I would say that I am the chief innovative officer in the company.

ZeClinics is a contract research organization (CRO) specializing in zebrafish research. Why was ZeClinics founded, and what are some of its core missions and values?

First and foremost, ZeClinics was founded on the basis of our expertise, which we felt could bring something new to the industry. As an academic, I had a lot of experience working with zebrafish. I was very much focused on basic research problems, but we understood from early on that the zebrafish could bring a lot of biological and experimental advantages to the industry that may be useful for drug discovery, target discovery, and understanding the safety of new compounds and more. So, we thought, ‘Why not?’. Why not create a company that can bring that expertise to the industry? Our company started small and has grown to 40 people – and we hope to grow more in the future.

In terms of core missions and values, I would say that our main mission is excellence and quality. We think – and hope – that we are always providing the best scientific output with the best quality, in terms of data management, in terms of scientific quality, and in terms of translatability of the results to humans.

I would say this excellence is what really drives us. The second mission that we have is to accelerate research. Within everything that we do, we seek to get drugs to patients earlier and at the lowest possible cost.

Continue reading… “Combining AI and Zebrafish to Accelerate Drug Discovery”
0

Abundant “Secret Doors” on Human Proteins Could Be Game-Changer for Drug Discovery

A three-dimensional animation of the human protein PSD95-PDZ3 showing the binding partner CRIPT (yellow) in the active site with the blue-to-red color gradient indicating increasing potential for allosteric effects. Based on PDB accession 1BE9.

By CENTER FOR GENOMIC REGULATION

Identification of hidden vulnerabilities on surface of ‘undruggable’ proteins could transform treatment of disease.

The number of potential therapeutic targets on the surfaces of human proteins is much greater than previously thought, according to the findings of a new study in the journal Nature.

A ground-breaking new technique developed by researchers at the Center for Genomic Regulation (CRG) in Barcelona has revealed the existence of a multitude of previously secret doors that control protein function and which could, in theory, be targeted to dramatically change the course of conditions as varied as dementia, cancer and infectious diseases.

The method, in which tens of thousands of experiments are performed at the same time, has been used to chart the first ever map of these elusive targets, also known as allosteric sites, in two of the most common human proteins, revealing they are abundant and identifiable.Official HCP Treatment Website – Partial-Onset Seizure InfoA Therapy Option May Reduce Your Patient’s Seizures. Learn Treatment Info Now.Prescription Treatment Website

The approach could be a game-changer for drug discovery, leading to safer, smarter and more effective medicines. It enables research labs around the world to find and exploit vulnerabilities in any protein – including those previously thought ‘undruggable’.

Continue reading… “Abundant “Secret Doors” on Human Proteins Could Be Game-Changer for Drug Discovery”
0

Liverpool Hospital trials smart gloves to train surgeons

Liverpool Hospital is trialling smart gloves that are said to provide surgical trainees with instant and accurate feedback.

The surgical gloves, invented by engineers at Western Sydney University, have been built around low-cost sensors which can record hand movements in fine detail, giving trainee surgeons and their mentors actionable data to evaluate and improve on intricate surgical procedures.

The research team are working closely with surgeons and students at Liverpool Hospital to develop the technology, which will augment rather than replace traditional surgical training.

Dr Gough Lui, who led the work, believes the device could objectively measure the intricate hand manoeuvres of surgeons, allowing for clear and actionable feedback for trainees.

“Training surgeons in a more objective and evidence-based manner ensures evidence-based competency. Teachers will be able to give precise feedback on minute details post-surgery, and students can analyse their performance,” Dr Lui said.

Continue reading… “Liverpool Hospital trials smart gloves to train surgeons”
0

A ‘game-changer’ weight-loss drug was approved in 2021. Demand was so high that there were shortages within months.


By Gabby Landsverk

  • Semaglutide, a weight-loss drug, showed promise for treating obesity in recent research.
  • Demand quickly exceeded supply after the FDA in June approved once-weekly semaglutide injections.
  • However, some experts worry that we don’t yet understand the drug’s long-term effects.

2021 was a historic year for obesity treatment. In June, the Food and Drug Administration approved the weight-loss drug semaglutide, which some experts described as a “game-changer.”

The medication, initially developed to treat Type 2 diabetes, was the first drug treatment to be approved by the FDA for weight management since 2014. Wegovy, the brand of semaglutide sold by Novo Nordisk, is a once-weekly injection designed to balance out hunger hormones. It’s prescribed for people with a body mass index of 30 or more, or a BMI of 27 with related conditions such as diabetes.

Semaglutide was widely praised, prompting such high demand that there were shortages within months of Wegovy’s entrance into the market.

While questions remain about its long-term effects, the drug made a splash in healthcare this year, changing how experts and the public think about weight loss.

Continue reading… “A ‘game-changer’ weight-loss drug was approved in 2021. Demand was so high that there were shortages within months.”
0

World’s first smart bandage detects multiple biomarkers for onsite chronic wound monitoring

By  National University of Singapore

A research team led by Professor Lim Chwee Teck from the National University of Singapore’s (NUS) Department of Biomedical Engineering and Institute for Health Innovation & Technology (iHealthtech), in collaboration with clinical partners from Singapore General Hospital, has developed a smart wearable sensor that can conduct real-time, point-of-care assessment of chronic wounds wirelessly via an app. A world’s first, the novel sensor technology can detect temperature, pH, bacteria type and inflammatory factors specific to chronic wounds within 15 minutes, hence enabling fast and accurate wound assessment.

With a rapidly aging population, healthcare providers are seeing more patients suffering from non-healing wounds such as diabetic foot and chronic venous leg ulcers. It has been estimated that about two percent of the world’s population suffer from chronic wounds. The healing processes for these chronic wounds are often interrupted due to reasons such as infection and repeated trauma, leading to severe stress, pain and discomfort to afflicted patients. For patients with diabetic foot ulcers, this can lead to more severe outcomes such as foot amputation. Timely care and proper treatment of chronic wounds are needed to speed up wound recovery. However, this requires multiple clinical visits for lengthy wound assessment and treatment, which adds to the healthcare cost. The NUS team’s innovation can help mitigate these consequences and relieve patients with chronic wounds from unnecessary distress.

The research was first published in the journal Science Advances on 21 May 2021.

Continue reading… “World’s first smart bandage detects multiple biomarkers for onsite chronic wound monitoring”
0

Life in 2050: A Glimpse at Medicine in the Future

By 2050, the ways in which we watch our health, seek medical advice, get treatment, and what we’re treated for will change dramatically.

By  Matthew S. Williams

Welcome back to the “Life in 2050” series. In previous installments, we looked at how technological advancements, climate change, and changes in the geopolitical landscape will alter the nature of warfare, economics, living at home, education, transportation, and space exploration (in two installments) in the coming decades.

Today, we will look at how these same changes and advancements will revolutionize medicine by the middle of this century. As with all the other aspects of life we’ve explored, this revolution is already well underway, but will accelerate dramatically as we get closer to 2050. This will present new opportunities for healthier living, but also new hazards.

Continue reading… “Life in 2050: A Glimpse at Medicine in the Future”
0

Third Rock-backed startup launches to develop cell therapies for MS, diabetes

“T Regulatory Cells” [Microscope image].

By Ned Pagliarulo

Five cancer cell therapies are approved in the U.S. Scores more are in clinical testing as drugmakers work to repurpose human cells as a platform for new medicines, many of which are similarly targeted at different types of cancer.

Continue reading… “Third Rock-backed startup launches to develop cell therapies for MS, diabetes”
0

‘Better treatments’: Government to fund psychedelic drugs trials to treat mental illness

Fungi containing psilocybin – otherwise known as magic mushrooms – will be part of government-funded trials into mental health treatments.

By Rob Harris

Clinical trials using magic mushrooms, ecstasy and other psychedelic drugs in potential breakthrough therapies for debilitating mental illnesses will be funded by the federal government as part of global efforts to advance innovative treatments.

There is growing international evidence showing substances such as ketamine, psilocybin and MDMA can successfully treat resistant mental illnesses, including depression and post-traumatic stress disorder, when used in a controlled environment and supported by psychiatric care.

Many standard treatments for illnesses, including addiction and eating disorders, can have varied efficacy and recovery rates and there have been few advances in novel pharmaceutical discoveries in recent years.

The Morrison government will on Wednesday launch a $15 million competitive grant round to kick-start Australian clinical trials of potential breakthrough combination therapies.

Continue reading… “‘Better treatments’: Government to fund psychedelic drugs trials to treat mental illness”
0

SCIENTISTS SUSPECT THIS DRUG CAN ACTUALLY DELAY AGING

By TONY TRAN

It’s the stuff of legend: a way to stop — or at least slow down — aging. 

Unlike Ponce de León searching for immortality in the swamps of Florida, though, a growing number of scientists now believe a treatment for Type 2 diabetes might be the key to slowing down the aging process, according to The Washington Post. 

More specifically, the scientists believe that the treatment — called metformin — can help prevent or slow down three age-related ailments: dementia, heart disease, and cancer. If metformin can effectively combat these diseases, it can also potentially extend our lifespan.

Note the language: it might extend our lifespan. Not make us immortal. 

Continue reading… “SCIENTISTS SUSPECT THIS DRUG CAN ACTUALLY DELAY AGING”
0