Researchers have induced a senescent-like state in worms by modifying the activity of the transcription factor TFEB. Under normal conditions, worms experience regeneration and signs of rejuvenation after fasting followed by refeeding. However, when TFEB is absent, this recovery fails to occur. Instead, the worms’ stem cells enter a state that closely resembles cellular senescence.
This senescent condition is characterized by several hallmark features: DNA damage, enlarged nucleoli, elevated levels of mitochondrial reactive oxygen species (ROS), and activation of inflammatory signals—all traits commonly observed in aging mammalian cells.
Continue reading… “New Model Uncovers How Cellular Senescence Is Triggered and Reversed in Worms”
