Breakthrough Method Supercharges Large Cancer Drugs by Hijacking Natural Cell Entry Pathway

A new scientific breakthrough could dramatically improve cancer treatments by helping bulky, hard-to-deliver drugs enter cells more efficiently.

Researchers from Duke University, the University of Texas Health Science Center at San Antonio, and the University of Arkansas have discovered a way to significantly boost the cellular uptake of a promising class of cancer therapies known as PROTACs. These drugs work by degrading harmful proteins in cells but are often too large to penetrate cell membranes on their own.

The team found that a naturally occurring cell surface protein, CD36, can act as a transporter, helping PROTACs cross the cellular barrier. By modifying the drugs to exploit this transport mechanism, the researchers achieved up to 22.3 times higher drug uptake, resulting in up to 23 times more powerful tumor suppression—all without sacrificing drug stability or solubility. Their findings, published April 17 in Cell, could breathe new life into many large-molecule drugs previously deemed too unwieldy for therapeutic use.

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Finger-Inspired Sensor Breakthrough Enhances Robotic Touch and Material Recognition

The development of increasingly advanced sensors is driving progress in fields such as robotics, security systems, virtual reality (VR), and high-tech prosthetics. Among these, multimodal tactile sensors—which detect various types of touch-related data like pressure, texture, and material composition—stand out for their potential to replicate the human sense of touch.

Despite significant advances in tactile sensor technology, two major challenges persist: detecting both the direction and magnitude of applied forces, and accurately identifying the materials that objects or surfaces are made from. Many existing sensors struggle to overcome these limitations.

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Scientists Develop Vascularized Lab-Grown Chicken for More Realistic Cultured Meat

Researchers at the University of Tokyo have developed a new method for growing lab-cultured chicken meat that mimics natural blood vessel systems, offering a potential breakthrough in the production of realistic, ethical alternatives to conventional meat. The team successfully produced nugget-sized pieces of chicken muscle using a bioreactor equipped with artificial vessels that deliver nutrients and oxygen evenly throughout the tissue—one of the major challenges in lab-grown meat production.

The innovation centers on a device called a perfusable hollow fiber bioreactor, which uses tiny, tube-like structures to replicate the function of blood vessels. These artificial vessels not only keep the cells alive by providing a steady supply of oxygen and nutrients but also guide muscle cell growth through microscopic anchors that help align the tissue properly.

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Singapore Researchers Turn Raindrops Into Efficient Renewable Energy Source

Researchers at the National University of Singapore have developed a novel system that can convert falling raindrops into usable electricity, enough to power 12 LEDs for 20 seconds. The innovation relies on a process called plug flow, where falling droplets move uniformly through a narrow vertical tube, maximizing the charge generated by each drop.

Led by Associate Professor Siowling Soh, the team demonstrated how this flow pattern significantly enhances the generation of electricity from water movement. Unlike conventional hydroelectric systems that require large-scale infrastructure and abundant water sources, this setup uses a simple, compact design involving a metallic needle and a 12-inch (32 cm) tall, 2-millimeter-wide polymer tube.

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Scientists Develop Self-Healing, Living Building Material with Mycelium and Bacteria

A team of researchers at Montana State University has created a novel living building material made from fungal mycelium and bacterial cells, capable of self-repair and extended viability. Unlike traditional construction materials, which are inert and resource-intensive, this bio-based composite remains alive and functional for weeks, offering a new frontier for sustainable and regenerative architecture.

The material is produced at low temperatures and incorporates living cells, drastically reducing the carbon footprint compared to conventional options like cement, which accounts for approximately 8% of global CO₂ emissions. According to lead researcher Dr. Chelsea Heveran, while the material is not yet strong enough to replace concrete in all structural applications, ongoing efforts aim to enhance its mechanical properties for broader use in the construction industry.

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Testing the Hypershell Exoskeleton on Ben Nevis: A Step Toward Tech-Enhanced Hiking

On a clear spring morning, a hiker tested the Hypershell exoskeleton—a wearable robotic leg brace designed to assist with walking and climbing—on Ben Nevis, the tallest mountain in the UK. Developed by Shanghai-based tech company Hypershell, the device uses AI-powered motors to reduce strain on the legs and enhance mobility, particularly on inclines and long treks.

Weighing approximately 4.4 pounds, the exoskeleton is worn around the waist and thighs and is powered by rechargeable batteries. It features three assistance modes—Eco, Transparent, and Hyper—which determine the level of support the motor provides. The system pairs with a smartphone app for control, though functionality may pose challenges for less tech-savvy users.

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KATRIN Experiment Pushes the Limits in the Search for Neutrino Mass

Neutrinos are among the most elusive and enigmatic particles in the universe. These ghost-like particles pass through matter—including our own bodies—almost entirely undetected. Yet, despite their abundance, much about neutrinos remains unknown, especially their mass. Unlocking this mystery is critical to deepening our understanding of both cosmology and fundamental particle physics, as even a tiny mass could point to new physics beyond the Standard Model.

At the forefront of this quest is the KATRIN experiment (Karlsruhe Tritium Neutrino), an international collaboration designed to make the most sensitive direct measurement of the neutrino’s mass. By observing beta decay—specifically the decay of tritium, a radioactive isotope of hydrogen—KATRIN analyzes the energy of electrons emitted in the process. Since energy conservation links the electron’s energy to that of the neutrino, any deviation can offer a precise estimate of the neutrino’s mass.

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Power from Pavement: New Cement Material Can Generate and Store Electricity

In a groundbreaking development, researchers in China have engineered a cement-based material that doesn’t just provide structural support—it can also generate and store electricity. This innovation, developed by a team led by Professor Zhou Yang at Southeast University, could pave the way for self-powered infrastructure in the smart cities of tomorrow.

The new material is a cement-hydrogel composite inspired by the internal structure of plant stems. This bioinspired design allows the material to capture thermal energy and convert it into electricity using the ionic thermoelectric effect. In terms of performance, it sets a new benchmark: the composite boasts a Seebeck coefficient of −40.5 mV/K and a figure of merit (ZT) of 6.6×10⁻²—approximately ten and six times higher, respectively, than previous cement-based thermoelectric materials.

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Whispers in the Wind: How Wind Phones Are Helping the World Grieve

Like many mothers and daughters, Amy and Emily Dawson once filled their phone calls with everything from life’s biggest moments to the everyday details. But now, Amy speaks to Emily through a phone that isn’t connected to any line. After Emily passed away from a terminal illness in 2020 at the age of 25, Amy found solace in creating a “wind phone”—a quiet place where words float into the air, carried by the breeze to someone who can no longer answer.

The idea behind the wind phone isn’t new. For millennia, people have imagined the wind as a messenger. In ancient Greece, the god Zephyrus used it to communicate. In Christianity, the Holy Spirit moves through it. But the modern wind phone offers something tangible—an actual phone to hold and speak into, helping mourners process grief in a personal and symbolic way.

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The Hidden Hardware Powering the Humanoid Revolution: Planetary Roller Screws Take Center Stage

The humanoid robotics revolution is fast approaching. Across the globe, test models are already working side-by-side with humans in factories, while AI companies race to develop advanced foundation models that enable robots to perceive and interact with the world as naturally as people do. But while much attention is focused on the artificial intelligence driving these machines, their physical forms—the “bodies” that make movement possible—are just as critical.

At the core of these robotic bodies are mechanical components like motors, gears, bearings, and screws. Among them, screws play a vital role by converting the rotational energy of motors into the linear motion humanoids need to walk, lift, or perform delicate tasks. Traditionally, ball screws—which use a circulating track of small balls between a threaded shaft and nut—have been the standard. But that’s starting to change.

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Chinese Scientists Develop Eco-Friendly Moss-Based Material to Revolutionize Oil Spill Cleanups

Chinese researchers have created a groundbreaking new material derived from moss that could significantly improve how we manage oil spills. A team from Guizhou Education University has modified sphagnum moss to absorb oil effectively while repelling water—offering a powerful new tool in environmental protection.

Oil spills, often caused by damaged oil rigs or burst pipelines, can devastate marine ecosystems and pose serious health risks to humans. Cleanup efforts can stretch over months or even years, underscoring the need for fast, efficient, and sustainable solutions.

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A Hidden Gateway: Scientists Uncover New Plant Tissue That Controls Seed Growth

Despite decades of research, the process of plant seed formation continues to surprise scientists. In a groundbreaking discovery, researchers from Nagoya University in Japan have identified an entirely new plant tissue—something that has remained undetected for over 160 years.

This newly discovered tissue, which resembles the shape of a rabbit, is the first of its kind to be identified since the mid-19th century. It plays a critical role in seed development, particularly in the transfer of nutrients after fertilization. At the center of this discovery is a structure now called the Kasahara Gateway, a crucial mechanism that regulates nutrient flow to the developing seed.

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