Attention deficit hyperactivity disorder (ADHD) affects millions worldwide, with profound impacts on both children and adults. Characterized by inattention, hyperactivity, and impulsivity, ADHD can significantly hinder academic and social functioning. While its genetic basis has long been acknowledged, identifying specific genes involved has remained a challenge. However, recent strides in research have illuminated a key player: the CDH2 gene.
Israeli scientists from Ben-Gurion University of the Negev and Soroka-University Medical Center have made a groundbreaking discovery, identifying CDH2 as a pivotal gene implicated in ADHD. CDH2 encodes N-cadherin, a protein essential for brain synapse activity and formation. Through meticulous investigation, researchers found that mutations in CDH2 disrupt synaptic activity, influencing molecular pathways and dopamine levels in brain regions associated with ADHD.
Continue reading… “Unveiling CDH2: A Genetic Breakthrough in Understanding ADHD”