A recent study published in the Journal of Cell Biology has illuminated the crucial role played by the enzyme GCN5 in maintaining the expression of key structural proteins in skeletal muscle. These proteins are essential for fundamental functions such as breathing, posture, and locomotion. Led by an international team of researchers from the Faculty of Medicine at the University of Ottawa, this discovery holds promise for future therapeutics targeting muscle degeneration caused by factors like aging, cancer, and muscular dystrophy.
Over a span of approximately five years, Dr. Keir Menzies, a molecular biologist at the Faculty of Medicine, and his team conducted experiments involving a muscle-specific mouse “knockout” of GCN5. This enzyme, known for regulating various cellular processes, was disrupted to understand its impact on muscle health during physical stress, such as downhill treadmill running.
Continue reading… “Unveiling the Key Role of GCN5 Enzyme: A Breakthrough in Understanding Muscle Health”