A research team at Uppsala University has developed an innovative method to produce three-dimensional motor nerve cell organoids using a patient’s own skin cells. This advancement aims to facilitate realistic laboratory testing of new therapeutic compounds targeting neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). The findings were published in the International Journal of Bioprinting.
ALS progressively damages motor neurons in the spinal cord, leading to muscle weakness and eventual respiratory failure. Direct testing on the spinal cord of affected individuals is not feasible due to medical limitations. To address this, the team led by Elena Kozlova created an in-vitro model. Skin-derived cells were reprogrammed into induced pluripotent stem cells, differentiated into motor neuron precursors, and embedded in a gelatinous hydrogel. These were then assembled layer by layer using 3D printing technology.
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