Category: Science & Technology News

Studying drug effects on human muscles just got easier thanks to a new “muscle-on-a-chip,” developed by a team of researchers from Penn’s School of Engineering and Applied Science and Inha University in Incheon, Korea.

Muscle tissue is essential to almost all of the body’s organs, however, diseases such as cancer and diabetes can cause muscle tissue degradation or “wasting,” severely decreasing organ function and quality of life. Traditional drug testing for treatment and prevention of muscle wasting is limited through animal studies, which do not capture the complexity of the human physiology, and human clinical trials, which are too time consuming to help current patients.

An “organ-on-a-chip” approach can solve these problems. By growing real human cells within microfabricated devices, an organ-on-a-chip provides a way for scientists to study replicas of human organs outside of the body.

Using their new muscle-on-a-chip, the researchers can safely run muscle injury experiments on human tissue, test targeted cancer drugs and supplements, and determine the best preventative treatment for muscle wasting.

In the U.S. and Europe alone, the disease causes $2.5bn in lost revenue annually.

By  Chris Young  

Researchers at Edinburgh University’s Roslin Institute are genetically engineering pigs to be more resistant to one of the deadliest animal diseases out there, a report by the BBC explains.

The disease in question, called Porcine Reproductive and Respiratory Syndrome (PRRS), was first recognized in the US in 1987. Symptoms include reproductive failure, pneumonia, and increased susceptibility to secondary bacterial infection, and it can cause pregnant sows to lose their litter.

The disease is responsible for approximately $560 million in lost revenue for farmers in the US each year, according to OiE. According to a press release from the University of Edinburgh, combined with losses in Europe, that number rises to $2.5bn in lost revenue annually. 

The same statement also says that vaccines have so far proven to be largely ineffective against the disease, which is endemic in most pig-producing countries.