A minimally invasive method holds promise for the treatment of neurological disorders and injury.
by Sue Min Liu
Iron oxide nanoparticles are incorporated into stem cells to create Cellbots
Korean researchers have devised a way to remotely direct stem cells to specific areas of the brain to promote neural tissue regeneration. They loaded iron oxide nanoparticles into the cells, which are then guided to the target site by an external magnetic source.
The research team, co-led by Professor Hongsoo Choi and Professor Sung Won Kim, report in Advanced Healthcare Materials that incorporating nanoparticles did not interfere with the viability or function of these stem cells, including their ability to differentiate into neurons.
Named Cellbots, the nanoparticle-containing stem cells were created using human stem cells harvested from the folds of tissue inside the nose — nasal turbinates — that are usually discarded after surgical procedures to alleviate nasal obstructions.
“Considering the frequency of this type of surgery, sufficient amounts of stem cells could be obtained for clinical trials. Characteristics of stem cells derived from nasal turbinate — including proliferative and differentiation potential, and immunophenotype — are not affected by passage number or the donor’s age, whereas other types of stem cells can be,” said Choi.Continue reading… “Magnetically-guided delivery of therapeutic stem cells into the brain”