Crumpled graphene makes ultra-sensitive cancer DNA detector

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Graphene-based biosensors could usher in an era of liquid biopsy, detecting DNA cancer markers circulating in a patient’s blood or serum. But current designs need a lot of DNA. In a new study, crumpling graphene makes it more than ten thousand times more sensitive to DNA by creating electrical “hot spots,” researchers at the University of Illinois at Urbana-Champaign found.

Crumpled graphene could be used in a wide array of biosensing applications for rapid diagnosis, the researchers said. They published their results in the journal Nature Communications.

“This sensor can detect ultra-low concentrations of molecules that are markers of disease, which is important for early diagnosis,” said study leader Rashid Bashir, a professor of bioengineering and the dean of the Grainger College of Engineering at Illinois. “It’s very sensitive, it’s low-cost, it’s easy to use, and it’s using graphene in a new way.”

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Old human cells rejuvenated with stem cell technology

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Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research.

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

The researchers also found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies.

The proteins, known as Yamanaka factors, are commonly used to transform adult cells into induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative medicine and drug discovery.

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YC startup Felix wants to replace antibiotics with programmable viruses

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Right now the world is at war. But this is no ordinary war. It’s a fight with an organism so small we can only detect it through use of a microscope — and if we don’t stop it, it could kill millions of us in the next several decades. No, I’m not talking about COVID-19, though that organism is the one on everyone’s mind right now. I’m talking about antibiotic-resistant bacteria.

You see, more than 700,000 people died globally from bacterial infections last year — 35,000 of them in the U.S. If we do nothing, that number could grow to 10 million annually by 2050, according to a United Nations report.

The problem? Antibiotic overuse at the doctor’s office or in livestock and farming practices. We used a lot of drugs over time to kill off all the bad bacteria — but it only killed off most, not all, of the bad bacteria. And, as the famous line from Jeff Goldblum in Jurassic Park goes, “life finds a way.”

Enter Felix, a biotech startup in the latest Y Combinator batch that thinks it has a novel approach to keeping bacterial infections at bay – viruses.

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A neural network can help spot Covid-19 in chest x-rays

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COVID-Net could help scientists develop an AI tool that can pick up telltale signs.

The news: An open-access neural network called COVID-Net, released to the public this week, could help researchers around the world in a joint effort to develop an AI tool that can test people for Covid-19.

What is it? COVID-Net is a convolutional neural network, a type of AI that is particularly good at recognizing images. Developed by Linda Wang and Alexander Wong at the University of Waterloo and the AI firm DarwinAI in Canada, COVID-Net was trained to identify signs of Covid-19 in chest x-rays using 5,941 images taken from 2,839 patients with various lung conditions, including bacterial infections, non-Covid viral infections, and Covid-19. The data set is being provided alongside the tool so that researchers—or anyone who wants to tinker—can explore and tweak it.

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Smartphone data reveal which Americans are social distancing (and not)

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D.C. gets an ‘A’ while Wyoming earns an ‘F’ for following coronavirus stay-at-home advice, based on the locations of tens of millions of phones

 Location data firm Unacast identified places where residents are engaging in more social distancing in green — and less in orange.

If you have a smartphone, you’re probably contributing to a massive coronavirus surveillance system.

And it’s revealing where Americans have — and haven’t — been practicing social distancing.

On Tuesday, a company called Unacast that collects and analyzes phone GPS location data launched a “Social Distancing Scoreboard” that grades, county by county, which residents are changing behavior at the urging of health officials. It uses the reduction in the total distance we travel as a rough index for whether we’re staying put at home.

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Stanford makes giant soft robot from inflatable tubes

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As much as we love soft robots (and we really love soft robots), the vast majority of them operate pneumatically (or hydraulically) at larger scales, especially when they need to exert significant amounts of force. This causes complications, because pneumatics and hydraulics generally require a pump somewhere to move fluid around, so you often see soft robots tethered to external and decidedly non-soft power sources. There’s nothing wrong with this, really, because there are plenty of challenges that you can still tackle that way, and there are some up-and-coming technologies that might result in soft pumps or gas generators.

Researchers at Stanford have developed a new kind of (mostly) soft robot based around a series of compliant, air-filled tubes. It’s human scale, moves around, doesn’t require a pump or tether, is more or less as safe as large robots get, and even manages to play a little bit of basketball.

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How to understand – and report – figures for ‘Covid deaths’

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Every day, now, we are seeing figures for ‘Covid deaths’. These numbers are often expressed on graphs showing an exponential rise. But care must be taken when reading (and reporting) these figures. Given the extraordinary response to the emergence of this virus, it’s vital to have a clear-eyed view of its progress and what the figures mean. The world of disease reporting has its own dynamics, ones that are worth understanding. How accurate, or comparable, are these figures comparing Covid-19 deaths in various countries?

We often see a ratio expressed: deaths, as a proportion of cases. The figure is taken as a sign of how lethal Covid-19 is, but the ratios vary wildly. In the US, 1.8 per cent (2,191 deaths in 124,686 confirmed cases), Italy 10.8 per cent, Spain 8.2 per cent, Germany 0.8 per cent, France 6.1 per cent, UK 6.0 per cent. A fifteen-fold difference in death rate for the same disease seems odd amongst such similar countries: all developed, all with good healthcare systems. All tackling the same disease.

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The coronavirus is showing us how clean the air can be if electric cars were the norm

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With all the loss of lives and financial destruction that the coronavirus has brought us, it’s hard to look at silver linings from this crisis, but there’s one that’s becoming obvious: cleaner air.

It might not last for long, but it’s giving us a glimpse at what we could experience if the world was to rapidly transition to electric transportation.

With shelter-in-place and stay-at-home orders all over the world, passenger car traffic has been way down and people have been burning way less petrol.

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Coronavirus: Robots use light beams to zap hospital viruses

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The UVD robot takes about 20 minutes to treat a room

“Please leave the room, close the door and start a disinfection,” says a voice from the robot.

“It says it in Chinese as well now,” Simon Ellison, vice president of UVD Robots, tells me as he demonstrates the machine.

Through a glass window we watch as the self-driving machine navigates a mock-hospital room, where it kills microbes with a zap of ultraviolet light.

“We had been growing the business at quite a high pace – but the coronavirus has kind of rocketed the demand,” says chief executive, Per Juul Nielsen.

He says “truckloads” of robots have been shipped to China, in particular Wuhan. Sales elsewhere in Asia, and Europe are also up.

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Researchers create stretchable super capacitors for our next wearables

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Carbon nanotube forests improve the stretchable supercapacitor’s performanceDuke University

The supercapacitors still functioned well when stretched to eight times their original size.

Imagine a new type of supercapacitor that can be repeatedly stretched to eight times its original size, yet still retaining its full functionality. Only after 10,000 cycles of charging and recharging does it start to lose a little percentage of its energy performance.

Researchers from Duke University and Michigan State University (MSU) have done just that. The team sees their novel supercapacitor as part of a power-independent, stretchable, flexible electronic system that could be used in wearable electronics or biomedical devices.

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Americans on the move to escape the coronavirus

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Lisa Pezzino brushes her teeth at her retreat in Big Sur, Calif., 140 miles from her city home in Oakland.

The mass migration looks urgent and temporary but might contain the seeds of a wholesale shift in where and how Americans live.

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Back home in Oakland, California, Lisa Pezzino and Kit Center built a life that revolved around music and the people who make it – the musicians who recorded on Pezzino’s small label and performed in places where Center rigged the lights and sound equipment.

Where they are now, deep in the redwood forest near Big Sur, 140 miles south along the California coast, there is mostly the towering silence of isolation. A tiny cabin, an outdoor kitchen, just one neighbor. This is life in the flight from the virus.

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Japanese spacecraft fired cannonball into asteroid

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The Japan Aerospace Exploration Agency’s (JAXA) Hayabusa2 spacecraft fired a copper cannonball into Ryugu, an 850 meter-wide near-Earth asteroid. The 2 kilogram “Small Carry-on Impactor,” a bit larger than a tennis ball, hit the asteroid at approximately 7,200 kilometers/hour and blew out a 14.5 meter wide crater with a depth of .6 meters. After a year of analysis, scientists have reported their analysis of the plume created by the impact and properties of the crater. From Space.com:

The number and size of craters that pockmark asteroids such as Ryugu can help scientists estimate the age and properties of asteroid surfaces. These analyses are based on models of how such craters form, and data from artificial impacts like that on Ryugu can help test those models…

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