Category: Healthcare

By Jackie Drees

Digital health and tech adoption have skyrocketed since the start of the COVID-19 pandemic, leaving many hospitals and health systems adopting technologies that support remote patient monitoring, two-way video communications and more. 

Here, five hospital executives share predictions for what they think the hospital room of the future will look like in the next five years. 

Continue reading… “The hospital room of the future: 5 innovation execs outline what to expect in next 5 years”

Interaction forces between magnetic particles translate into macroscopic transformations of the smart polymers

by Carlos III University of Madrid

Developing a new generation of artificial muscles and soft nanorobots for drug delivery are some of the long-term goals of 4D-BIOMAP, an ERC research project being undertaken by the Universidad Carlos III de Madrid (UC3M).This project develops cross-cutting bio-magneto-mechanical methodologies to stimulate and control biological processes such as cell migration and proliferation, the organism’s electrophysiological response, and the origin and development of soft tissue pathologies.

“The overarching idea of this research project is to influence different biological processes at the cellular level (i.e., wound healing, brain synapses or nervous system responses) by developing timely engineering applications,” explains 4D-BIOMAP’s lead researcher, Daniel García González from the UC3M’s Department of Continuum Mechanics and Structural Analysis.

Continue reading… “Smart magnetic soft materials to develop artificial muscles and therapeutic robots”

Gold nanoparticles embedded in a porous hydrogel can be implanted under the skin and used as medical sensors. The sensor is like an invisible tattoo revealing concentration changes of substances in the blood by color change. Credit: Nanobiotechnology Group, JGU Department of Chemistry

By Universitaet Mainz

The idea of implantable sensors that continuously transmit information on vital values and concentrations of substances or drugs in the body has fascinated physicians and scientists for a long time. Such sensors enable the constant monitoring of disease progression and therapeutic success. However, until now, implantable sensors have not been suitable to remain in the body permanently and require replacement after a few days or weeks.

There is also the problem of implant rejection as the immune system recognizes the sensor as a foreign object. With many technologies, the sensor’s color, which indicates concentration changes, is unstable and fades over time. Scientists at Johannes Gutenberg University Mainz (JGU) have developed a novel type of implantable sensor that can be implanted in the body for several months. The sensor is based on color-stable gold nanoparticles that are modified with receptors for specific molecules. Embedded into an artificial polymeric tissue, the nanogold is implanted under the skin, where it reports changes in drug concentrations by changing its color.

Professor Carsten Soennichsen’s research group at JGU has been using gold nanoparticles as sensors to detect tiny amounts of proteins in microscopic flow cells for many years. Gold nanoparticles act as small antennas for light: They strongly absorb and scatter it, and appear colorful. They react to alterations in their surrounding by changing color. Soennichsen’s team has exploited this concept for implanted medical sensing.

Continue reading… “Tattoo made of gold nanoparticles revolutionizes medical diagnostics”

by Ludwig Maximilian University of Munich

a TEM image (left, reproduced at least 3 times) and sketches (right) of the DNA origami structure used for the nanoantenna assembly with the position of the plasmonic hotspot indicated in red. A representative class averaged TEM image of the DNA origami used is shown on the upper right. b Schematics of NACHOS assembly: the DNA origami construct is bound to the BSA-biotin coated surface via biotin-NeutrAvidin interactions, thiolated DNA-functionalized 100 nm silver particles are attached to the DNA origami nanoantenna via polyadenine (A20) binding strands in the zipper-like geometry to minimize the distance between the origami and the nanoparticles30. c TEM image of a NACHOS with 100 nm silver nanoparticles (reproduced at least 3 times). d Single-molecule fluorescence intensity transients, measured by confocal microscopy, normalized to the same excitation power of a single Alexa Fluor 647 dye incorporated in a DNA origami (orange) and in a DNA origami nanoantenna with two 100 nm silver nanoparticles (blue) excited at 639 nm e. Fluorescence enhancement distribution of Alexa Fluor 647 measured in NACHOS with 100 nm silver nanoparticles. A total number of 164 and 449 single molecules in the reference (more examples are provided in Supplementary Fig. 3) and NACHOS structures were analyzed, respectively. Credit: Nature Communications (2021). DOI: 10.1038/s41467-021-21238-9

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics.

Biomarkers play a central role in the diagnosis of disease and assessment of its course. Among the markers now in use are genes, proteins, hormones, lipids and other classes of molecules. Biomarkers can be found in the blood, in cerebrospinal fluid, urine and various types of tissues, but most of them have one thing in common: They occur in extremely low concentrations, and are therefore technically challenging to detect and quantify.

Many detection procedures use molecular probes, such as antibodies or short nucleic-acid sequences, which are designed to bind to specific biomarkers. When a probe recognizes and binds to its target, chemical or physical reactions give rise to fluorescence signals. Such methods work well, provided they are sensitive enough to recognize the relevant biomarker in a high percentage of all patients who carry it in their blood. In addition, before such fluorescence-based tests can be used in practice, the biomarkers themselves or their signals must be amplified. The ultimate goal is to enable medical screening to be carried out directly on patients, without having to send the samples to a distant laboratory for analysis.

Continue reading… “Detecting single molecules and diagnosing diseases with a smartphone”

Secure and reliable virtual access to healthcare professionals and data has become table stakes for us to meet our 21st century challenges and goals.

By Morris Panner

We will look back on 2020 as a pivotal moment for the use of cloud computing in healthcare. As the pandemic swept away old constraints, digital health innovators rushed in. In the face of a major crisis, providers and technologists worked tirelessly to make healthcare better, pushing change to save lives. Innovation and entrepreneurship don’t come without risk, but they also can provide enormous benefits. Collecting and sharing data via the cloud will enable a healthcare system fit for the 21st century. 

This kind of change doesn’t happen overnight. The banking industry for example is reaping the benefits of a major digital transformation that was driven by cloud adoption over the last decade. Until now healthcare providers have been reticent to embrace the same kind of IT modernization. Concerns about security, legal compliance, and potential downtime when dealing with the most sensitive personal data in life and death situations are all legitimate, but can all be addressed. Secure and reliable virtual access to healthcare professionals and data has become table stakes for us to meet our 21st-century challenges and goals.

Continue reading… “The Future of Healthcare Is in the Cloud”