Advance in CAR T-cell therapy eliminates severe side effects

9462BBC5-4F9E-44BE-8060-D2F28918C5AAScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAID

An advance in the breakthrough cancer treatment known as CAR T-cell therapy appears to eliminate its severe side effects, making the treatment safer and potentially available in outpatient settings, a new USC study shows.

“This is a major improvement,” said Si-Yi Chen of the USC Norris Comprehensive Cancer Center, professor in the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC, and senior author of the study appearing online April 22 in Nature Medicine. “We’ve made a new CAR molecule that’s just as efficient at killing cancer cells, but it works more slowly and with less toxicity.”

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New gene therapy wipes out leukemia in three patients

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The new gene therapy to treat leukemia uses the patients’ own blood cells to hunt down and wipe out their cancer.

The first clear success with gene therapy to treat leukemia, turning the patients’ own blood cells into assasins that hunt down and wipe out their cancer has been reported by scientists at the University of Pennsylvania.

 

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Hexavalent Chromium, the Carcinogen Made Famous by Erin Brockovich, Found in Cities Across U.S.

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Julia Roberts played Erin Brockovich in the film of the same name.

The domestic tap water of 31 out of 35 United States cities surveyed contains hexavalent chromium, the probable carcinogen made famous by the film Erin Brockovich, according to an environmental report.

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Mechanism Behind Organ Transplant Rejection Identified

Heart-transplant blood vessel in chronic rejection

UCLA researchers have pinpointed the culprit behind chronic rejection of heart, lung and kidney transplants. Published in the Nov. 23 edition of Science Signaling, their findings suggest new therapeutic approaches for preventing transplant rejection and sabotaging cancer growth.

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Cancer Patients to Get Blood Transfusions Made From Their Own Skin

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Medical breakthrough for cancer patients

Patients could soon be transfused with blood made from their own skin in a breakthrough that could revolutionise cancer treatments and solve the blood donor shortage. Scientists have shown that ordinary skin cells can effectively be converted into adult blood cells in the laboratory.

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Engineering Could Give Reconstructive Surgery a Facelift

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Using engineering design methods, researchers model custom bone replacement implants for facial reconstruction surgery.

Facial reconstruction patients may soon have the option of custom-made bone replacements optimized for both form and function, thanks to researchers at the University of Illinois and the Ohio State University Medical Center.

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Surgeons Transplant New Trachea Into Child Using His Own Stem Cells to Rebuild Airway

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Still image from a video showing a visualization of the transplantation operation using the new trachea.

UCL scientists and surgeons have led a revolutionary operation to transplant a new trachea into a child, using the child’s own stem cells to rebuild the airway in the body.

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Growing Cartilage: Bioactive Nanomaterial Promotes Growth of New Cartilage

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3D illustration of the knee. Damaged cartilage can lead to joint pain and loss of physical function and eventually to osteoarthritis.

Northwestern University researchers are the first to design a bioactive nanomaterial that promotes the growth of new cartilage in vivo and without the use of expensive growth factors. Minimally invasive, the therapy activates the bone marrow stem cells and produces natural cartilage. No conventional therapy can do this.

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Gene Therapy Technique Slows Brain Disease ALD Featured In Movie ‘Lorenzo’s Oil’

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This figure represents four cells, four purified CD34+ (the CD34+ cell population comprises true hematopoetic stem cell) from patient P1.

A strategy that combines gene therapy with blood stem cell therapy may be a useful tool for treating a fatal brain disease, French researchers have found.

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Experimental Approach May Reverse Rheumatoid Arthritis And Osteoporosis

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A newly identified mechanism may keep a well known signaling molecule from eroding bone and inflaming joints — a finding that may yield new treatments for osteoporosis and rheumatoid arthritis.

Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical Investigation. Continue reading… “Experimental Approach May Reverse Rheumatoid Arthritis And Osteoporosis”

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Formaldehyde Linked To More Common Cancers

Formaldehyde Linked To More Common Cancers 

Doctors fear tens of thousands of children were exposed to dangerous levels of the cancer-causing agent formaldehyde in the post-Katrina FEMA trailers and could have lifelong illnesses.

New research raises additional concerns about the harmful effects of formaldehyde, a common chemical found in everything from plywood to nail polish, car exhaust and cigarette smoke.

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