Researchers have successfully gene-edited chickens to enhance their resistance to bird flu, presenting a potential strategy for safeguarding poultry flocks against future outbreaks. Amid a severe avian flu outbreak since 2021, scientists at the University of Edinburgh explored the use of CRISPR technology to modify genes in chicken cells, specifically targeting the ANP32A protein used by all subtypes of the bird flu virus for replication.
The researchers altered two amino acids in ANP32A, preventing the virus from replicating in the edited chicken cells. Embryos were then gene-edited, resulting in ten chickens with the modified form of ANP32A. When exposed to the H9N2 subtype of bird flu, known for causing milder illness than H5N1, only one gene-edited chicken out of ten became infected, compared to all non-edited chickens.
Continue reading… “Gene-Edited Chickens Show Promise in Developing Resistance to Bird Flu”
