AI tool could predict how drugs will react in the body

 

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“The safety of a drug does not depend only on the drug itself but also on the metabolites
that can be formed when the drug is processed in the body,” says Eleni Litsa

A new deep learning-based tool called Metabolic Translator may soon give researchers a better handle on how drugs in development will perform in the human body.

When you take a medication, you want to know precisely what it does. Pharmaceutical companies go through extensive testing to ensure that you do.

Metabolic Translator, a computational tool that predicts metabolites, the products of interactions between small molecules like drugs and enzymes could help improve the process.

The new tool takes advantage of deep-learning methods and the availability of massive reaction datasets to give developers a broad picture of what a drug will do. The method is unconstrained by rules that companies use to determine metabolic reactions, opening a path to new discoveries.

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New flexible 3D graphene supercapacitors

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An electron microscope image shows the cross section of laser-induced graphene burned into both sides of a polyimide substrate.

By producing and testing stacked, three-dimensional supercapacitors — energy-storage devices that are important for portable, flexible electronics, Rice University scientists have advanced their recent development of laser-induced graphene (LIG). Continue reading… “New flexible 3D graphene supercapacitors”

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Self-Strengthening Polymer Nanocomposite Works Best Under Pressure

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Polymer Nanocomposite

No one keeps carbon nanotubes down — especially not these guys. The always popular allotropes have been enlisted by researchers at Rice University to create a composite material that gets stronger under pressure. When combined with polydimethylsiloxane, a rubbery polymer, the tubes form a nanocomposite that exhibits self-strengthening properties also exhibited in bones. During testing, the team found the material increased in stiffness by 12 percent after 3.5 million compressions…

Continue reading… “Self-Strengthening Polymer Nanocomposite Works Best Under Pressure”

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