Senolytic therapies seem to stop Alzheimer’s disease ‘in its tracks’

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Scientists at the University of Texas have implicated a type of cellular stress for the first time as a player in Alzheimer’s disease. And their discovery could lead to treatments for more than 20 human brain diseases including Alzheimer’s and traumatic brain injury. One author of the study went as far as to say the treatment that researchers used on mice to rid them of the stressed cells actually stopped Alzheimer’s disease “in its tracks.”

Researchers at the The University of Texas Health Science Center at San Antonio, now called UT Health San Antonio® established a link between tau tangles and the stressed or senescent cells they found in Alzheimer’s-diseased tissue. Senescence is the process by which cells irreversibly stop dividing or growing without actually dying. Already proven to be involved in cancer and aging, tau protein accumulation is known to exist in 20 human brain diseases. “Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease, progressive supranuclear palsy (PSP), traumatic brain injury (TBI) and over twenty others,” the research paper notes.

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Electrical Stimulation Through The Spinal Cord May Ease Parkinson’s Symptoms

Electrical Stimulation Through The Spinal Cord May Ease Parkinson’s Symptoms

Neural activity in the brain of a Parkinsonian rat before (top) and after (bottom) electrical stimulation is applied to its spinal cord.  

Delivering electrical stimulation to the spinal cord through tiny, platinum electrodes could ease the severe motor deficits of Parkinson’s disease as effectively as a much more intrusive procedure currently in clinical use, according to a new study in rodents. If the findings are confirmed in humans, scientists say, the procedure could dramatically improve treatment for the disease by making electrical therapies safer and more broadly available.

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Horseback Riding Eases Back Pain And Boosts Confidence

Horseback Riding Eases Back Pain And Boosts Confidence 

Riding on horseback not only eases back pain, but also boosts the rider’s confidence and emotional well being, according to a new study.   The findings contribute to the growing body of evidence that horseback riding and related equine assistance therapy programs for disabled and injured individuals benefit human participants.

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Transplanted Stem Cells Undo Birth Defects

Transplanted Stem Cells Undo Birth Defects 

 Neural stem cells, tagged green with a fluorescent dye, have been transplanted among the brain cells (red) of a mouse born with brain damage after its mother was given heroin during pregnancy.

By injecting stem cells directly into the brain, scientists have successfully reversed neural birth defects in mice whose mothers were given heroin during pregnancy. Even though most of the transplanted cells did not survive, they induced the brain’s own cells to carry out extensive repairs.

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Nano-sized “Cargo Ships” Developed To Carry Anti-Cancer Drugs And Markers Through The Body

Nano-sized “Cargo Ships” Developed To Carry Anti-Cancer Drugs And Markers Through The Body 

 The nanometer-sized cargo ships look individually like a chocolate-covered nut cluster, in which a biocompatible lipid forms the chocolate shell and magnetic nanoparticles, quantum dots and the drug doxorubicin are the nuts.

Scientists have developed nanometer-sized ‘cargo ships’ that can sail throughout the body via the bloodstream without immediate detection from the body’s immune radar system and ferry their cargo of anti-cancer drugs and markers into tumors that might otherwise go untreated or undetected.

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