The company was founded to commercialise a peptide ligation reaction developed by Jeffrey Bode’s research group
BY VANESSA ZAINZINGER
Bright Peak Therapeutics makes modified protein drugs from scratch.
Jeffrey Bode from ETH Zurich in Switzerland has a fitting analogy for why synthetic proteins are a compelling next step for the development of therapeutic molecules. ‘Almost all modern antibiotics have been found or produced in nature, but were then modified with synthetic chemistry to make a better drug,’ he says. ‘In the same way, natural proteins often have fantastic biological activity but limitations in terms of, for example, toxicity. They can be made better and safer by using synthetic chemistry.’
Bode is a co-founder of Bright Peak Therapeutics, a privately held biotechnology company based in San Diego, US, and Basel, Switzerland, that is commercialising fully synthetic proteins for use in cancer immunotherapy and autoimmune diseases.
The company’s most advanced product is a synthetic version of cytokine signalling protein interleukin-2 called BPT-143. It is currently in chemistry, manufacturing and controls (CMC) manufacturing – an integral part of any pharmaceutical product application to the US Food and Drug Administration (FDA), in which the manufacturing process, testing regimes and and product characteristics are developed to ensure they are consistent across batches. ‘As far as we know, no one has brought such a sophisticated synthetic molecule so far along clinical development,’ Bode says.
Continue reading… “Fully synthetic proteins make tailored medicines”
