Fully synthetic proteins make tailored medicines

The company was founded to commercialise a peptide ligation reaction developed by Jeffrey Bode’s research group

BY VANESSA ZAINZINGER

Bright Peak Therapeutics makes modified protein drugs from scratch.

Jeffrey Bode from ETH Zurich in Switzerland has a fitting analogy for why synthetic proteins are a compelling next step for the development of therapeutic molecules. ‘Almost all modern antibiotics have been found or produced in nature, but were then modified with synthetic chemistry to make a better drug,’ he says. ‘In the same way, natural proteins often have fantastic biological activity but limitations in terms of, for example, toxicity. They can be made better and safer by using synthetic chemistry.’

Bode is a co-founder of Bright Peak Therapeutics, a privately held biotechnology company based in San Diego, US, and Basel, Switzerland, that is commercialising fully synthetic proteins for use in cancer immunotherapy and autoimmune diseases.

The company’s most advanced product is a synthetic version of cytokine signalling protein interleukin-2 called BPT-143. It is currently in chemistry, manufacturing and controls (CMC) manufacturing – an integral part of any pharmaceutical product application to the US Food and Drug Administration (FDA), in which the manufacturing process, testing regimes and and product characteristics are developed to ensure they are consistent across batches. ‘As far as we know, no one has brought such a sophisticated synthetic molecule so far along clinical development,’ Bode says.

Continue reading… “Fully synthetic proteins make tailored medicines”

SPACE MACHINES TO DEPLOY FLEET SPACE NANOSATELLITES

Australian in-space transportation provider, Space Machines Company (SMC) has announced two deals, linking with an Italian satellite services provider and committing to deploy Fleet Space nanosatellites in orbit next year.

Space Machines linked up with Italian satellite services provider Leaf Space to support its Optimus-1 satellite launch timed for next year.

Optimus-1, the largest commercial satellite under construction in Australia, is an orbital transfer vehicle providing cost-effective insertion of small satellites into low Earth orbit.

Today Space Machines confirmed a memorandum of understanding (MoU) to test the deployment of nanosatellites from Fleet Space Technologies, the Adelaide nanosatellite manufacturer for the Internet of Things (IoT). 

The first mission will analyse the suitability of Optimus to deliver Fleet’s satellites into orbit. 

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Iteris develops a new AI sensor system for smart cities and traffic management

Recently, Iteris announced the development of a new AI-powered sensor system that can detect, monitor, and manage traffic. What challenges do growing cities face, what does the system provided by Iteris offer, and what problems can integrated smart systems face?

 By Robin Mitchell

What challenges do growing cities face?

As the world population grows, so does the demand for transportation services, whether it be increased use in buses, taxis, or privately owned vehicles. While the current climate crisis is changing how vehicles are made and what sources of energy they use, it has little impact on the increasing number of vehicles. Using public transport may be better for the environment, but poor availability and inconvenience leads many to privately own vehicles.

Most roads around the world were laid during a time of significantly fewer vehicles, and these roads may have been designed with a few decades of vehicle growth in mind. If the demand on a road increases to the point where traffic starts to build up, it is often impossible to widen the road and add lanes as roads often have buildings on either side.

This leads us to a new challenge where modern road networks are quickly becoming congested. Congested traffic is not only bad for waiting times, but it also results in increased emissions from vehicles and can increase the chances of collisions and accidents.

For traffic management to improve, smart cities will need to be introduced, which involve the placement of sensors and smart technologies that allow computers to take over control in real-time. Simply put, a smart city would recognise key areas of congestion and then redirect traffic to improve safety while reducing waiting times. Furthermore, a smart city would be able to more efficiently control signals at traffic lights to prevent severe congestion forming while making better decisions on when to let pedestrian’s crossroads.

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Swift Medical Launches AI Digital Wound App to Support Clinical Trials

by Jasmine Pennic 

What You Should Know:

Global digital wound care provider Swift Medical, today announced the launch of a new application specifically designed to help pharma and med device researchers conduct decentralized clinical trials. Since patients are now doing more trials at home, study coordinators have had trouble tracking skin side effects remotely — or trusting patients to conduct adequate analysis and recording on themselves.

– Swift Medical’s first product, Swift Skin and Wound, provides an AI-powered, digital wound platform that allows any patient or clinician to easily capture high-precision images of skin or wound conditions with any smartphone camera. Swift Skin and Wound autonomously determines clinical characteristics, tracks disease progression, enables remote communication, and securely shares patient data in real-time.

To date, Swift Medical’s technology is used by more than 4,000 healthcare organizations internationally, including health systems and providers of all kinds, academic institutions, research organizations and pharmaceutical companies.

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Healthcare Logistics Turns Futuristic with Drone Blood Delivery

Wingcopter

By Brielle Jaekel

The current pandemic exposes many gaps in the healthcare supply chain, leading many to look for innovative solutions. Wingcopter undergoes drone delivery testing for blood samples to help this.

Wingcopter completes a successful test transport of blood samples in Germany via drone delivery, speeding up important healthcare drop offs in rural areas. Without technologies such as this, life saving deliveries can be difficult in rural areas, making innovative projects like this so timely. The journey for the Wingcopter drone was roughly 16 miles, or 26 kilometers, in just 18 minutes with a pneumatic tube including 250 grams of blood samples in tow. 

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I spoke to 5,000 people and these are the real reasons they’re quitting

BY KIM SEELING SMITH

If you are like most managers, you probably frequently ask yourself:

“How do I get the best out of my team?”

“What truly motivates them?”

“How can I help them unlock their potential?”

You may also ask, especially around performance review time, “How can I manage their performance without a lot of stress or sweaty-palm-inducing conversations?”

There have been reams of information written about employee motivation and performance over the last 100 years. But we’ve found there are nine key factors that impact these metrics—and they are much more important than pay and benefits.

I call these nine factors the Currencies of Choice. I discovered them as the result of reverse-engineering during 5,000 exit interviews I conducted with an international team of recruiters over the course of 15 years.

This research, along with numerous studies from organizations and managers who regularly use the Currencies of Choice model, shows that intrinsic motivators are much more effective in keeping employees motivated and engaged—and helping them perform well and realize their potential—than pay and benefits.

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UK’s future force to lean heavily into robotics, AI and hybrid power

A British soldier launches a drone during an exercise on the Defence Ministry’s training area at Salisbury Plain on Oct. 13, 2020.

By Jen Judson 

WASHINGTON — The British Army is leaning heavily into robotics, artificial intelligence and hybrid-power technology as part of a new acquisition process dubbed Mercury, according to a British Army leader involved in future procurement planning.

The Army is grappling with how to acquire technologies that it believes it will need in the future, how to spiral in those technologies across its equipment programs and how to cultivate skills in its soldiers to use capabilities as they come online, Col. Christopher Coton, the service’s assistant head for concepts, said at the DSEI defense exhibition in London on Sept. 15.

Driving innovation to achieve its goals, the Army must better identify technologies that will likely change the way the service operates and fights, Coton said. This would be done by drawing on traditional and nontraditional suppliers, the officer added, and the service needs to better articulate what it needs to both small and large companies capable of helping to co-develop technology along the way.

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An entire street of 3D printed homes in Texas are move-in ready

Written by KC Morganon

This is East 17th Street, a collection of homes that range in size and style. It’s got beautiful construction, lovely walkways and landscaping. But what truly makes this Austin, Texas project unique is that these are the first 3D-printed homes for sale in America. Yes, you read that correctly. These homes were all made with a 3D printer.

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Chinese manufacturer vows flying cars by 2024

A Xpeng Motor Heitech flying vehicle on display in Shanghai in April.

Xpeng Heitech, a flying car start-up backed by electric vehicle maker Xpeng Inc, says it will deliver flying cars to customers in 2024.

The start-up, founded in 2013 and funded by Xpeng and Xpeng’s chief executive He Xiaopeng, employs 400 people and will expand its workforce to have 700 people by the end of this year, company founder Zhao Deli told World New Energy Vehicle Congress.

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VIRAL PANTHERS CLIP A ‘MILESTONE IN AUGMENTED REALITY’

The Carolina Panthers’ viral moment was months in the making. COURTESY CAROLINA PANTHERS

BY JACOB FELDMAN

People had gotten used to virtual fans—floating heads along the sideline of the NBA Finals or avatars in the outfield bleachers at MLB games. But on Sunday, with NFL stadiums full again, augmented reality took center stage once more, this time in the form of a CGI panther standing on the 50-yard line.

By Tuesday, Carolina’s mixed reality clip of a massive feline leaping around Bank of America Stadium, and seemingly shredding a Jets banner in the process, had drawn more than 10 million views online. The video received more impressions than any other NFL team post during Week 1, according to Zoomph. Meanwhile, Panthers executives were already fielding requests from potential sponsors, as they plan to bring the project back for future home games.

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Companies are coworking in the metaverse to stave off Zoom burnout and spark new types of collaboration

by Alexander Lee

During the COVID-19 pandemic, many companies have adopted virtual communication tools to make up for in-person collaboration, but those channels have come with limitations: the nonverbal cues that make in-person meetings useful are difficult to discern on Zoom, and there’s no virtual replacement for water cooler conversations. 

As the pandemic drags on, some firms are addressing these shortcomings by coworking in the metaverse.

It doesn’t help that Zoom burnout is real. Struggling to pick up on nonverbal communication, constantly having to look at oneself and conversing in immobile digital environments are all contributing factors to a national rise in “Zoom fatigue” over the past year, according to a February study by Stanford University’s Virtual Human Interaction Lab. “We can’t just open up new lines of communication organically in Zoom,” said Daniel Liebeskind, CEO of metaverse platform Topia. “It’s just not possible.”

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Firm raises $15m to bring back woolly mammoth from extinction

The remains of a well-preserved baby mammoth, named Lyuba, displayed in Hong Kong in 2012. 

By Ian Sample

Scientists set initial sights on creating elephant-mammoth hybrid, with first calves expected in six years.

Ten thousand years after woolly mammoths vanished from the face of the Earth, scientists are embarking on an ambitious project to bring the beasts back to the Arctic tundra.

The prospect of recreating mammoths and returning them to the wild has been discussed – seriously at times – for more than a decade, but on Monday researchers announced fresh funding they believe could make their dream a reality.

The boost comes in the form of $15m (£11m) raised by the bioscience and genetics company Colossal, co-founded by Ben Lamm, a tech and software entrepreneur, and George Church, a professor of genetics at Harvard Medical School who has pioneered new approaches to gene editing.

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Discover the Hidden Patterns of Tomorrow with Futurist Thomas Frey
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By delving into the futuring techniques of Futurist Thomas Frey, you’ll embark on an enlightening journey.

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