Mouse With Human Liver: New Model for Treatment of Liver Disease

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Mice whose own liver cells have been replaced with human hepatocytes (shown in green) can be successfully infected with hepatitis B virus (shown in red) providing a new way to test novel therapies for debilitating human liver diseases.

How do you study-and try to cure in the laboratory-an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. This “humanized” mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.

Continue reading… “Mouse With Human Liver: New Model for Treatment of Liver Disease”

Trigger Of Deadly Food Toxin Discovered; Finding Could Help Prevent Liver Cancer

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UCI scientist Sheryl Tsai and colleagues have discovered what triggers a cancer-causing toxin to form on nuts and grains, which could lead to methods of limiting its production

A toxin produced by mold on nuts and grains can cause liver cancer if consumed in large quantities. UC Irvine researchers for the first time have discovered what triggers the toxin to form, which could lead to methods of limiting its production.

Continue reading… “Trigger Of Deadly Food Toxin Discovered; Finding Could Help Prevent Liver Cancer”

Second-hand Smoking Results In Liver Disease, Study Finds

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The image shows sections though livers of mice. Mice exposed to second-hand smoke in the lab accumulated excess fat in their liver cells.

A team of scientists at the University of California, Riverside has found that even second-hand tobacco smoke exposure can result in nonalcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury in which fat accumulates in the liver of people who drink little or no alcohol. Continue reading… “Second-hand Smoking Results In Liver Disease, Study Finds”