
Mice whose own liver cells have been replaced with human hepatocytes (shown in green) can be successfully infected with hepatitis B virus (shown in red) providing a new way to test novel therapies for debilitating human liver diseases.
How do you study-and try to cure in the laboratory-an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. This “humanized” mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.
Continue reading… “Mouse With Human Liver: New Model for Treatment of Liver Disease”