heart attack

The size of a heart attack and the harm it causes a patient can depend on what time it strikes.

Heart attacks are worst when they take place between 1 am and 5 am, acccording to a study published in Circulation Research.

Researchers say the size of the heart attack and the subsequent left-ventricular function is significantly different based on the time of the attack. A study in humans, published online in the reputed journal, Circulation Research, says ‘the greatest amount of injury to the heart occurs when individuals have a heart attack between 1 am and 5 am’.

Indian doctors agreed. Dr Ramakant Panda, cardiac surgeon at Asian Heart Institute, said, “There are different phases of sleep. Early morning sleep is called rapid eye movement sleep during which people dream. The body is asleep but the mind is awake. The autonomous nervous system is stimulated which releases hormones such as adrenaline, noradrenaline and cortisol. These hormones increase the activity if the heart which beats and works harder. But the hormones constrict the blood supply to the heart.”

Chairman of Escorts Heart Institute Dr Ashok Seth said, “Also, one main reason why heart attacks are worst at night is because people wait till morning to go and get an ECG. Initially, they rubbish it by thinking its indigestion and take some antacids.”

“We were trying to ascertain whether the time of day of when a heart attack occurs influences the amount of damage that the heart sustains, or was this just a phenomenon exhibited in rodents,” said the study’s senior author Jay H Traverse, a cardiologist at Minneapolis Heart.

An analysis of 1,031 patients of acute heart attack referred for primary percutaneous coronary intervention with known ischemic times between one and six hours, identified 165 patients with their first heart attack who had blocked arteries.

All 165 patients had well-defined ischemic times and the data were supported by data on size of heart attack, and area-at-risk.

The researchers observed that the extent of infarct size was significantly associated with time of day onset of infarction.

What are the implications of these findings? It is important to understand that the heart’s ability to protect itself against more severe damage varies over a 24-hour cycle. Identifying those protective changes may be particularly relevant for pharmaceutical manufacturers that are seeking to develop cardioprotective drugs, Traverse added.

Photo credit: Straits Times

Via Times of India

0