Graduate research associate Jordan Moore reviews brain MRI images of mice in the nanomedicine lab at The Ohio State University College of Medicine. In a new study, researchers demonstrate the potential of a new cell therapy to reverse damage from ischemic stroke by regrowing blood vessels and healthy brain tissue. Credit: The Ohio State University Wexner Medical Center
Most stroke victims don’t receive treatment fast enough to prevent brain damage. Scientists at The Ohio State University Wexner Medical Center, College of Engineering and College of Medicine have developed technology to “retrain” cells to help repair damaged brain tissue. It’s an advancement that may someday help patients regain speech, cognition and motor function, even when administered days after an ischemic stroke.
Engineering and medical researchers use a process created by Ohio State called tissue nanotransfection (TNT) to introduce genetic material into cells. This allows them to reprogram skin cells to become something different—in this case vascular cells—to help fix damaged brain tissue.
Study findings published online today in the journal Science Advances.
In this mouse study, cells were ‘pre-conditioned’ with specific genes and injected into the stroke-affected brains, where they promoted the formation of new blood vessels via reprogramming and the repair of damaged brain tissue.
“We can rewrite the genetic code of skin cells so that they can become blood vessel cells,” said Daniel Gallego-Perez, an assistant professor of biomedical engineering and surgery at Ohio State who is leading the research. “When they’re deployed into the brain, they’re able to grow new, healthy vascular tissue to restore normal blood supply and aid in the repair of damaged brain tissue.”
Researchers studied the process in mice and found that those treated with this innovative cell therapy regained 90% of their motor function. MRI scans showed damaged areas of the brain were repaired within a few weeks.
Continue reading… “New technology ‘retrains’ cells to repair damaged brain tissue in mice after stroke”
