Molecular machinery that makes potent antibiotic revealed after decades of research


Discovery by Rutgers and other scientists could lead to new antibiotics and anticancer drugs

The 3D structure of McbBCD, an enzyme (protein) that makes the potent antibiotic microcin B17 from a smaller protein known as a peptide, as revealed by X-ray crystallography. The red spheres show chemical “cycles” formed by the enzyme that are required for antibacterial activity.

Scientists at Rutgers and universities in Russia, Poland and England have solved a nearly 30-year mystery – how the molecular machinery works in an enzyme that makes a potent antibiotic.

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Cockroaches Could Be Used to Develop Treatments Against MRSA and E.coli


Cockroaches contain powerful antibiotic molecules in their brains.

Cockroaches and locusts contain powerful antibiotic molecules in their brains that could be used to develop new treatments against MRSA and E-coli, scientists have discovered.  Scientists at Nottingham University found that the insects, which are widely reviled for their dirty image, could actually be more of a health benefit than a health risk.


Nanoscale Imaging

Nanoscale Imaging 

Donut shaped blood cells

By using nanoptical scanning probe microscopes, scientists are able to reveal the going-ons inside humans and animals with stunning clarity. Take the above set of donut-shaped blood cells – which have been treated with an antibiotic called phyllomelittin taken from the skin of a monkey frog – now decidedly more appetizing than when in a normal, bloody-looking state. (I’m sure many of you relaxed back into your seat Homer Simpson-style with an “Mmm… Monkey frog donuts…”)

Continue reading… “Nanoscale Imaging”