By Kevin Lin 

Scientists have designed a temporary, battery-free pacemaker that can be broken down by the patient’s body when its work is done, the latest advance in the emerging field of bioelectronics.

In a paper published this week in Nature Biotechnology, researchers report that the device reliably kept the heart’s pace in check in tests on mice, rats, and other animals, as well as in human heart tissue in a dish. And while the research is still in the early stages, the scientists say the pacemaker was able to overcome key limitations of existing devices.

“There are about 1 million people a year who receive pacemaker implantations worldwide. It’s a huge, huge medical field, but mostly pacemakers are permanent,” said Igor Efimov, a biomedical engineer and professor at George Washington University and co-author of the new paper.

Unlike traditional pacemakers, which are left inside a patient for the rest of their life or until the battery dies, a traditional temporary pacemaker is implanted and later removed. The devices are typically for children with congenital heart defects or adults who have had a coronary artery bypass graft, who may need a temporary pacemaker to correct a slowed heart rhythm for only a few days or weeks.

Patrick Doherty volunteered for a new medical intervention of gene-editor infusions for the treatment of genetically-based diseases.Patrick Doherty

Patrick Doherty had always been very active. He trekked the Himalayas and hiked trails in Spain.

But about a year and a half ago, he noticed pins and needles in his fingers and toes. His feet got cold. And then he started getting out of breath any time he walked his dog up the hills of County Donegal in Ireland where he lives.

“I noticed on some of the larger hill climbs I was getting a bit breathless,” says Doherty, 65. “So I realized something was wrong.”

Doherty found out he had a rare, but devastating inherited disease — known as transthyretin amyloidosis — that had killed his father. A misshapen protein was building up in his body, destroying important tissues, such as nerves in his hands and feet and his heart.

By Vanesa Listek

A team of engineers and health experts led by mechanics professor Ricky Wildman from the University of Nottingham, UK, found a new way to design and manufacture custom medical devices to boost performance and bacterial resistance. Using a combination of multi-material inkjet 3D printing and genetic algorithms, the researchers designed tailored composite artificial body parts and other medical devices with built-in functionality that offer better shape and durability while cutting the risk of bacterial infection at the same time. The study opens the possibility of a new manufacturing concept to produce devices with spatially distributed, customizable material functionalities in a cost-effective manner.