In a groundbreaking finding, researchers have developed a technology that can help effectively treat heart diseases in humans. The technology repairs heart muscles in mice after a heart attack and also successfully regenerates them. Researchers, from the University of Houston, have used a synthetic messenger ribonucleic acid (mRNA) to deliver mutated transcription factors to the heart of the mouse. The transcription factors are the proteins that control the conversion of DNA into RNA.
In their study, published in The Journal of Cardiovascular Aging, the team conducted an experiment to show that two mutated transcription factors, Stemin and YAP5SA, work closely to increase the replication of heart muscle cells or cardiomyocytes in mice.
“What we are trying to do is dedifferentiate the cardiomyocyte into a more stem cell-like state so that they can regenerate and proliferate,” said Siyu Xiao, Ph.D graduate and co-author of the study. According to another co-author Dinakar Iyer, Stemin transcription proved to be a game-changer in their experiment. While Stemin triggers stem-like properties in cardiomyocytes, YAP5SA works on organ growth resulting in more replication of the myocytes.
Continue reading… “New Technology Can Repair Heart Muscles After an Attack, Say Researchers”