In mammals, only 3% of the genome encodes proteins essential for life and development. However, genes do not operate in isolation; they are regulated by other DNA sequences known as enhancers, which function like switches to turn genes on or off. Researchers at the University of Geneva (UNIGE) have identified 2,700 enhancers that regulate genes involved in bone growth.
Our height is largely inherited, and many genetic diseases impact bone growth. The root cause of these conditions might lie not in the genes themselves, but in the enhancers that activate them. Guillaume Andrey, a researcher at UNIGE, explains that enhancers signal DNA to produce RNA, which in turn synthesizes proteins. While the locations of bone growth genes are known, the specific enhancers controlling them had remained elusive.
Continue reading… “Enhancers: The Hidden Switches Controlling Bone Growth Genes”