Preclinical study evaluated treatments for diabetes, Crohn’s disease, and other conditions that use injectable meds using an orally administered capsule
Newswise — Biologic drugs—so named because they are typically isolated from a living source, rather than chemically synthesized—are used to treat a wide variety of conditions, including diabetes, inflammatory diseases, and certain types of cancer. However, due to their complex and easily degradable components, the administration of these drugs often requires a self-injection, which can represent burdens for patients, such as necessary training for proper self-administration and the potential for needle stick injuries and pain. Now, NIBIB-funded researchers are developing a robotic pill that, after swallowing, can deliver biologic drugs into the stomach, which could potentially revolutionize the way that certain conditions are treated.
“Due to the inherent drawbacks of injectable medications, many healthcare professionals prescribe less effective oral medications in their place, resulting in suboptimal treatment for many patients,” said David Rampulla, Ph.D., director of the division of Discovery Science & Technology at NIBIB. “An oral pill for the delivery of biologic drugs would not only positively impact those patients who already use injectable medications, but could also benefit patients that are currently delaying their use. This preclinical research is an important step toward the development of such an approach.”
Continue reading… “Robotic pill can orally deliver large doses of biologic drugs”

