Analyzing the plasma proteins of patients with sepsis can provide critical insights into the severity and prognosis of the condition, researchers report. Their findings demonstrate how affordable, high-throughput proteomics using mass spectrometry (MS) can effectively map the plasma proteome, revealing differences in patient responses.
The study, published in Science Translational Medicine, identified three distinct clusters of sepsis patients based on their plasma proteomes. These clusters were indicative of the patients’ response states, disease severity, and outcomes. The researchers found that a patient’s assignment to a particular cluster could change over time, suggesting potential applications for therapeutic intervention and disease progression monitoring.
Continue reading… “Plasma Proteomics: A New Frontier in Sepsis Diagnosis and Prognosis”