Close-up of a cylinder in a Melt Electrowriting system showing a printed heart valve scaffold. Credit: Andreas Heddergott / TUM
Researchers have developed 3D printed artificial heart valves designed to allow a patient’s own cells to form new tissue. To form these scaffolds using melt electrowriting—an advanced additive manufacturing technique—the team has created a new fabrication platform that enables them to combine different precise, customized patterns and hence to fine-tune the scaffold’s mechanical properties. Their long-term goal is to create implants for children that develop into new tissue and therefore last a lifetime.
In the human body, four heart valves ensure that blood flows in the correct direction. It is essential that heart valves open and close properly. To fulfill this function, heart valve tissue is heterogeneous, meaning that heart valves display different biomechanical properties within the same tissue.
A team of researchers working with Petra Mela, Professor of Medical Materials and Implants at the Technical University of Munich (TUM), and Professor Elena De-Juan Pardo from The University of Western Australia, have now, for the first time, imitated this heterogeneous structure using a 3D printing process called melt electrowriting. To do this, they have developed a platform that facilitates printing precise customized patterns and their combination, which enabled them to fine-tune different mechanical properties within the same scaffold.
Continue reading… “3D printed, bioinspired heart valves: Scaffolds created by melt electrowriting aim to support new tissue formation”
