Nanobiologic approach trains the innate immune system to eliminate tumor cells

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A groundbreaking new type of cancer immunotherapy developed at the Icahn School of Medicine at Mount Sinai trains the innate immune system to help it eliminate tumor cells through the use of nanobiologics, tiny materials bioengineered from natural molecules that are paired with a therapeutic component, according to a study published in Cell in October.

This nanobiologic immunotherapy targets the bone marrow, where part of the immune system is formed, and activates a process called trained immunity. This process reprograms bone marrow progenitor cells to produce “trained” innate immune cells that halt the growth of cancer, which is normally able to protect itself from the immune system with the help of other types of cells, called immunosuppressive cells.

This work for the first time demonstrates that trained immunity can be successfully and safely induced for the treatment of cancer. The research was performed in animal models, including a mouse model with melanoma, and the researchers said it is being developed for clinical testing.

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How scientists built a ‘living drug’ to beat cancer

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IN 2010, EMILY Whitehead was diagnosed with Acute Lymphoblastic Leukemia, a cancer of certain cells in the immune system.

THIS IS THE most common form of childhood cancer, her parents were told, and Emily had a good chance to beat it with chemotherapy. Remission rates for the most common variety were around 85 percent.

It would be 20 months before they’d understand the shadow behind that sunny statistic, and the chilling prospect of volunteering their daughter as patient zero for the world’s first living drug.

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An ‘EpiPen’ for spinal cord injuries

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ANN ARBOR—An injection of nanoparticles can prevent the body’s immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis.

The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells—call it an “EpiPen” for trauma to the central nervous system, which includes the brain and spinal cord.

“In this work, we demonstrate that instead of overcoming an immune response, we can co-opt the immune response to work for us to promote the therapeutic response,” said Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering.

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The end of chemotherapy? Scientists discover all cancerous cells have a KILL CODE that can be triggered without the gruelling treatment

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Researchers at Northwestern University found that our cells can kill themselves

Currently, this is triggered by disease itself or the artificial use of chemotherapy

Now, experts believe the ‘kill codes’ could be synthetically duplicated for use

Every cell in the human body contains a ‘kill code’ which can be triggered to cause its own self-destruction.

That’s the discovery made by researchers at Northwestern University, Illinois, who believe it could be utilised for the future fight against cancer.

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Reprogrammed cells could fight ‘untreatable’ diseases in the future

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Loring (front row, center) with the Loring Lab Group at the Center for Regenerative Medicine.

Jeanne Loring, director of the Center for Regenerative Medicine at Scripps Research Institute, and her colleagues transplanted a set of cells into the spinal cords of mice that had lost use of their hind limbs to multiple sclerosis. Within a week, as the experimentalists had expected, the mice rejected the cells. But after another week, the mice began to walk.

 

 

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New gene therapy wipes out leukemia in three patients

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The new gene therapy to treat leukemia uses the patients’ own blood cells to hunt down and wipe out their cancer.

The first clear success with gene therapy to treat leukemia, turning the patients’ own blood cells into assasins that hunt down and wipe out their cancer has been reported by scientists at the University of Pennsylvania.

 

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Revolutionary Skin Patch Could Cure Peanut Allergy

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The aim of the skin patch is to educate the body so it doesnt over-react to peanut exposure.

A revolutionary skin patch that may cure thousands of deadly peanut allergy has been developed by pediatricans. Researchers believe it presents one of the best possible ways of finding an effective treatment for a life threatening reaction to peanuts.

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