A cell cultured on top of the nanowire scaffold.
New nanotechnology that accelerates the transition of stem cells into bone could transform regenerative medicine.
A nanotechnology platform developed by King Abdullah University of Science & Technology (KAUST) scientists could lead to new treatments for degenerative bone diseases.
The technique relies on iron nanowires that bend in response to magnetic fields. Bone-forming stem cells grown on a mesh of these tiny wires get a kind of physical workout on the moving substrate. They subsequently grow into adult bone considerably quicker than in conventional culturing settings, with a differentiation protocol that lasts only a few days rather than a few weeks.
“This is a remarkable finding,” says Jasmeen Merzaban, associate Professor of bioscience. “We can achieve efficient bone cell formation in a shorter amount of time,” potentially paving the way for more efficient regeneration of bone. Merzaban co-led the study together with sensor scientist Jürgen Kosel and colleagues from their labs.
The scientists analyzed the bone-producing capability of their nanowire scaffold, both with and without magnetic signals. They patterned the tiny wires in an evenly spaced grid and then layered bone marrow-derived human mesenchymal stem cells (MSCs) on top. Each of the tiny wires is about the size of the tail-like appendage found on some bacteria.
Continue reading… “Nanotechnology Advances Regenerative Medicine: Bone Formation Comes Down to the Nanowire”
