by Emily Henderson, B.Sc.

A functional precision medicine study conducted in Finland demonstrates that treatment selection based on results from drug sensitivity testing of patients’ cells can be clinically useful in patients with aggressive hematological cancers.

Clinicians, researchers and technology experts from the Institute for Molecular Medicine Finland FIMM at the University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center have over the last 10 years developed and tested a functional precision medicine approach to assign therapies to individual cancer patients. Their latest results have just been published in Cancer Discovery, a top-tier journal of the American Association for Cancer Research.

The group has focused on patients with hematological cancers, particularly acute myeloid leukemia (AML), since standard therapies for the advanced forms of these malignancies have a limited effect and the outcome is invariably poor.

Researchers have developed fish-shaped microrobots that are guided with magnets to cancer cells. 

No, it’s not from a science fiction movie or from an episode of a popular kid’s television show. It’s real life. Researchers, in a proof-of-concept study, have made fish-shaped microrobots that are guided with magnets to cancer cells, where a pH change triggers them to open their mouths and release their chemotherapy cargo.

Scientists have previously made microscale (smaller than 100 µm) robots that can manipulate tiny objects, but most can’t change their shapes to perform complex tasks, such as releasing drugs. Some groups have made 4D-printed objects (3D-printed devices that change shape in response to certain stimuli), but they typically perform only simple actions, and their motion can’t be controlled remotely.

Fish-shaped microrobots are guided with magnets to cancer cells, where they open their mouths to release their chemotherapy cargo.

Bu Katie Cottingham

Delivering drugs directly to cancer cells could help reduce chemotherapy’s unpleasant symptoms.

Chemotherapy successfully treats many forms of cancer, but the side effects can wreak havoc on the rest of the body. Delivering drugs directly to cancer cells could help reduce these unpleasant symptoms. Now, in a proof-of-concept study, researchers reporting in ACS Nano made fish-shaped microrobots that are guided with magnets to cancer cells, where a pH change triggers them to open their mouths and release their chemotherapy cargo.